Cargando…

Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells

Niemann–Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC treatment, and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoque, Sanzana, Kondo, Yuki, Sakata, Nodoka, Yamada, Yusei, Fukaura, Madoka, Higashi, Taishi, Motoyama, Keiichi, Arima, Hidetoshi, Higaki, Katsumi, Hayashi, Akio, Komiya, Takaki, Ishitsuka, Yoichi, Irie, Tetsumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038050/ https://www.ncbi.nlm.nih.gov/pubmed/32019132 http://dx.doi.org/10.3390/ijms21030898

Ejemplares similares

Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models()
por: Tanaka, Yuta, et al.
Publicado: (2014)

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice
por: Fukaura, Madoka, et al.
Publicado: (2021)

2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent
por: Yokoo, Masako, et al.
Publicado: (2015)

In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C
por: Yasmin, Nushrat, et al.
Publicado: (2019)

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
por: Yamada, Yusei, et al.
Publicado: (2023)

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells
por: Motoyama, Keiichi, et al.
Publicado: (2017)

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease
por: Maeda, Yuki, et al.
Publicado: (2019)

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells
por: Motoyama, Keiichi, et al.
Publicado: (2015)

Effects of intracerebroventricular administration of 2-hydroxypropyl-β-cyclodextrin in a patient with Niemann–Pick Type C disease
por: Matsuo, Muneaki, et al.
Publicado: (2014)

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
por: Arima, Hidetoshi, et al.
Publicado: (2011)

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
por: Arima, Hidetoshi, et al.
Publicado: (2012)

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death
por: Hoshiko, Toshimi, et al.
Publicado: (2021)

Potential use of Folate-appended Methyl-β-Cyclodextrin as an Anticancer Agent
por: Onodera, Risako, et al.
Publicado: (2013)

2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy
por: Singhal, Ashutosh, et al.
Publicado: (2020)

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin
por: Kameyama, Kazuhisa, et al.
Publicado: (2017)

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier
por: Hayashida, Kayoko, et al.
Publicado: (2014)

A marked paucity of granule cells in the developing cerebellum of the Npc1(−/−) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin
por: Nusca, S., et al.
Publicado: (2014)

Involvement of Autophagy in Antitumor Activity of Folate-appended Methyl-β-cyclodextrin
por: Onodera, Risako, et al.
Publicado: (2014)

Hydroxypropyl-β-cyclodextrin Enhances Oral Absorption of Silymarin Nanoparticles Prepared Using PureNano™ Continuous Crystallizer
por: Onodera, Risako, et al.
Publicado: (2022)

Nanoparticles of folic acid‐methyl‐β‐cyclodextrin (FA‐MβCD)/adamantane‐albumin exhibit enhanced antitumor activity compared with FA‐MβCD alone
por: Sakai, Aiko, et al.
Publicado: (2022)

Encapsulation Mechanism of Oxyresveratrol by β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin and Computational Analysis
por: He, Jianfei, et al.
Publicado: (2017)

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation
por: Wathoni, Nasrul, et al.
Publicado: (2020)

The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
por: Zhang, Li, et al.
Publicado: (2018)

Pharmacokinetic Properties of Fluorescently Labelled Hydroxypropyl-Beta-Cyclodextrin
por: Váradi, Judit, et al.
Publicado: (2019)

Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats
por: Uehata, Keiko, et al.
Publicado: (2011)

Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin
por: Wen, Jiping, et al.
Publicado: (2010)

Enhanced Solubilization of Fluoranthene by Hydroxypropyl β-Cyclodextrin Oligomer for Bioremediation
por: Park, Kyeong Hui, et al.
Publicado: (2018)

Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin
por: Ding, Yili, et al.
Publicado: (2020)

Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment
por: Houben, Tom, et al.
Publicado: (2021)

Combinations of Piperine with Hydroxypropyl-β-Cyclodextrin as a Multifunctional System
por: Stasiłowicz, Anna, et al.
Publicado: (2021)

Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex
por: Gao, Shuang, et al.
Publicado: (2019)

Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
por: Veszelka, Szilvia, et al.
Publicado: (2022)

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
por: Arima, Hidetoshi, et al.
Publicado: (2009)

Stability, Antioxidant Activity and Intestinal Permeation of Oleuropein Inclusion Complexes with Beta-Cyclodextrin and Hydroxypropyl-Beta-Cyclodextrin
por: Liu, Hui, et al.
Publicado: (2022)

Solid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex
por: Ghodke, D. S., et al.
Publicado: (2010)

Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl-β-Cyclodextrin
por: Benfeito, Sofia, et al.
Publicado: (2013)

2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques
por: Sá Couto, André Rodrigues, et al.
Publicado: (2018)

Development and Characterization of a Tacrolimus/Hydroxypropyl-β-Cyclodextrin Eye Drop
por: García-Otero, Xurxo, et al.
Publicado: (2021)

Synthesis and Characterization of Phenolic Acid/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes
por: Kim, Ji-Sang
Publicado: (2020)

Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds
por: Swingler, Sam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8pjbjad0adseid5msdchab64u6