Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

The incidence of gastrointestinal cancers is increasing every year. Irinotecan (CPT-11), a drug used in the treatment of colorectal cancer and gastric cancer, is metabolized by carboxylesterases to an active metabolite, SN-38, which is more cytotoxic. CAPE (caffeic acid phenethyl ester) is an active...

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Detalles Bibliográficos
Autores principales: Gajek, Gabriela, Marciniak, Beata, Lewkowski, Jarosław, Kontek, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038052/
https://www.ncbi.nlm.nih.gov/pubmed/32033066
http://dx.doi.org/10.3390/molecules25030658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038052/
https://www.ncbi.nlm.nih.gov/pubmed/32033066
http://dx.doi.org/10.3390/molecules25030658

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