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The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-depen...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038166/ https://www.ncbi.nlm.nih.gov/pubmed/31973188 http://dx.doi.org/10.3390/ijms21030709 |
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author | Manzano-López, Javier Monje-Casas, Fernando |
author_facet | Manzano-López, Javier Monje-Casas, Fernando |
author_sort | Manzano-López, Javier |
collection | PubMed |
description | The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase. |
format | Online Article Text |
id | pubmed-7038166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70381662020-03-10 The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control Manzano-López, Javier Monje-Casas, Fernando Int J Mol Sci Review The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase. MDPI 2020-01-21 /pmc/articles/PMC7038166/ /pubmed/31973188 http://dx.doi.org/10.3390/ijms21030709 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Manzano-López, Javier Monje-Casas, Fernando The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title | The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title_full | The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title_fullStr | The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title_full_unstemmed | The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title_short | The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control |
title_sort | multiple roles of the cdc14 phosphatase in cell cycle control |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038166/ https://www.ncbi.nlm.nih.gov/pubmed/31973188 http://dx.doi.org/10.3390/ijms21030709 |
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