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The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control

The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-depen...

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Autores principales: Manzano-López, Javier, Monje-Casas, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038166/
https://www.ncbi.nlm.nih.gov/pubmed/31973188
http://dx.doi.org/10.3390/ijms21030709
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author Manzano-López, Javier
Monje-Casas, Fernando
author_facet Manzano-López, Javier
Monje-Casas, Fernando
author_sort Manzano-López, Javier
collection PubMed
description The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.
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spelling pubmed-70381662020-03-10 The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control Manzano-López, Javier Monje-Casas, Fernando Int J Mol Sci Review The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase. MDPI 2020-01-21 /pmc/articles/PMC7038166/ /pubmed/31973188 http://dx.doi.org/10.3390/ijms21030709 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manzano-López, Javier
Monje-Casas, Fernando
The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title_full The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title_fullStr The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title_full_unstemmed The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title_short The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
title_sort multiple roles of the cdc14 phosphatase in cell cycle control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038166/
https://www.ncbi.nlm.nih.gov/pubmed/31973188
http://dx.doi.org/10.3390/ijms21030709
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