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Synthesis of Biologically Active Molecules through Multicomponent Reactions

Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules ar...

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Detalles Bibliográficos
Autores principales: Insuasty, Daniel, Castillo, Juan, Becerra, Diana, Rojas, Hugo, Abonia, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038231/
https://www.ncbi.nlm.nih.gov/pubmed/31991635
http://dx.doi.org/10.3390/molecules25030505
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author Insuasty, Daniel
Castillo, Juan
Becerra, Diana
Rojas, Hugo
Abonia, Rodrigo
author_facet Insuasty, Daniel
Castillo, Juan
Becerra, Diana
Rojas, Hugo
Abonia, Rodrigo
author_sort Insuasty, Daniel
collection PubMed
description Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.
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spelling pubmed-70382312020-03-09 Synthesis of Biologically Active Molecules through Multicomponent Reactions Insuasty, Daniel Castillo, Juan Becerra, Diana Rojas, Hugo Abonia, Rodrigo Molecules Review Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review. MDPI 2020-01-24 /pmc/articles/PMC7038231/ /pubmed/31991635 http://dx.doi.org/10.3390/molecules25030505 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Insuasty, Daniel
Castillo, Juan
Becerra, Diana
Rojas, Hugo
Abonia, Rodrigo
Synthesis of Biologically Active Molecules through Multicomponent Reactions
title Synthesis of Biologically Active Molecules through Multicomponent Reactions
title_full Synthesis of Biologically Active Molecules through Multicomponent Reactions
title_fullStr Synthesis of Biologically Active Molecules through Multicomponent Reactions
title_full_unstemmed Synthesis of Biologically Active Molecules through Multicomponent Reactions
title_short Synthesis of Biologically Active Molecules through Multicomponent Reactions
title_sort synthesis of biologically active molecules through multicomponent reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038231/
https://www.ncbi.nlm.nih.gov/pubmed/31991635
http://dx.doi.org/10.3390/molecules25030505
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