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Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium. Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannopro...

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Detalles Bibliográficos
Autores principales:	Alkhazraji, Sondus, Gebremariam, Teclegiorgis, Alqarihi, Abdullah, Gu, Yiyou, Mamouei, Zeinab, Singh, Shakti, Wiederhold, Nathan P., Shaw, Karen J., Ibrahim, Ashraf S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038288/ https://www.ncbi.nlm.nih.gov/pubmed/31818813 http://dx.doi.org/10.1128/AAC.01735-19

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