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On the Immunological Consequences of Conventionally Fractionated Radiotherapy

Emerging evidence demonstrates that radiotherapy induces immunogenic death on tumor cells that emit immunostimulating signals resulting in tumor-specific immune responses. However, the impact of tumor features and microenvironmental factors on the efficacy of radiation-induced immunity remains to be...

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Autores principales: Alfonso, Juan Carlos L., Papaxenopoulou, Lito A., Mascheroni, Pietro, Meyer-Hermann, Michael, Hatzikirou, Haralampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038527/
https://www.ncbi.nlm.nih.gov/pubmed/32092699
http://dx.doi.org/10.1016/j.isci.2020.100897
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author Alfonso, Juan Carlos L.
Papaxenopoulou, Lito A.
Mascheroni, Pietro
Meyer-Hermann, Michael
Hatzikirou, Haralampos
author_facet Alfonso, Juan Carlos L.
Papaxenopoulou, Lito A.
Mascheroni, Pietro
Meyer-Hermann, Michael
Hatzikirou, Haralampos
author_sort Alfonso, Juan Carlos L.
collection PubMed
description Emerging evidence demonstrates that radiotherapy induces immunogenic death on tumor cells that emit immunostimulating signals resulting in tumor-specific immune responses. However, the impact of tumor features and microenvironmental factors on the efficacy of radiation-induced immunity remains to be elucidated. Herein, we use a calibrated model of tumor-effector cell interactions to investigate the potential benefits and immunological consequences of radiotherapy. Simulations analysis suggests that radiotherapy success depends on the functional tumor vascularity extent and reveals that the pre-treatment tumor size is not a consistent determinant of treatment outcomes. The one-size-fits-all approach of conventionally fractionated radiotherapy is predicted to result in some overtreated patients. In addition, model simulations also suggest that an arbitrary increase in treatment duration does not necessarily result in better tumor control. This study highlights the potential benefits of tumor-immune ecosystem profiling during treatment planning to better harness the immunogenic potential of radiotherapy.
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spelling pubmed-70385272020-03-02 On the Immunological Consequences of Conventionally Fractionated Radiotherapy Alfonso, Juan Carlos L. Papaxenopoulou, Lito A. Mascheroni, Pietro Meyer-Hermann, Michael Hatzikirou, Haralampos iScience Article Emerging evidence demonstrates that radiotherapy induces immunogenic death on tumor cells that emit immunostimulating signals resulting in tumor-specific immune responses. However, the impact of tumor features and microenvironmental factors on the efficacy of radiation-induced immunity remains to be elucidated. Herein, we use a calibrated model of tumor-effector cell interactions to investigate the potential benefits and immunological consequences of radiotherapy. Simulations analysis suggests that radiotherapy success depends on the functional tumor vascularity extent and reveals that the pre-treatment tumor size is not a consistent determinant of treatment outcomes. The one-size-fits-all approach of conventionally fractionated radiotherapy is predicted to result in some overtreated patients. In addition, model simulations also suggest that an arbitrary increase in treatment duration does not necessarily result in better tumor control. This study highlights the potential benefits of tumor-immune ecosystem profiling during treatment planning to better harness the immunogenic potential of radiotherapy. Elsevier 2020-02-11 /pmc/articles/PMC7038527/ /pubmed/32092699 http://dx.doi.org/10.1016/j.isci.2020.100897 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alfonso, Juan Carlos L.
Papaxenopoulou, Lito A.
Mascheroni, Pietro
Meyer-Hermann, Michael
Hatzikirou, Haralampos
On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title_full On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title_fullStr On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title_full_unstemmed On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title_short On the Immunological Consequences of Conventionally Fractionated Radiotherapy
title_sort on the immunological consequences of conventionally fractionated radiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038527/
https://www.ncbi.nlm.nih.gov/pubmed/32092699
http://dx.doi.org/10.1016/j.isci.2020.100897
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