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Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study

BACKGROUND: Three-dimensional 3D-CRT: conformal radiation therapy is a selective modality in many radiotherapy centers for the treatment of breast cancer. One of the most common side effects of this method is radiation lung injury. Considering such an injury, lung dose deserves to be studied in dept...

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Autores principales: Abdemanafi, Mahsa, Tavakoli, Mohammad Bagher, Akhavan, Ali, Abedi, Iraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038741/
https://www.ncbi.nlm.nih.gov/pubmed/32166077
http://dx.doi.org/10.4103/jmss.JMSS_1_19
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author Abdemanafi, Mahsa
Tavakoli, Mohammad Bagher
Akhavan, Ali
Abedi, Iraj
author_facet Abdemanafi, Mahsa
Tavakoli, Mohammad Bagher
Akhavan, Ali
Abedi, Iraj
author_sort Abdemanafi, Mahsa
collection PubMed
description BACKGROUND: Three-dimensional 3D-CRT: conformal radiation therapy is a selective modality in many radiotherapy centers for the treatment of breast cancer. One of the most common side effects of this method is radiation lung injury. Considering such an injury, lung dose deserves to be studied in depth. METHODS: Computed tomography scan of a node-positive left-sided breast cancer woman was used for generating a thorax phantom. Ten thermoluminescent dosimeters (TLDs) were distributed evenly in the left lung of the phantom, and the phantom was scanned. The optimal plan, including supraclavicular and tangential fields, was created by the treatment planning system (TPS). The results of TLD dose measurements at the selected points in the phantom were compared to TPS dose calculations. RESULTS: Lung doses calculated by TPS are significantly different from those measured by the TLDs (P = 0.007). The minimum and maximum differences were −0.91% and 4.46%, respectively. TLDs that were on the inner margin of the lung and breast tissue showed higher dose differences than the TLDs in the lung. CONCLUSION: The results of this study showed that TPS generally overestimated doses compared to TLD measurements due to incorrect beam modeling caused by contaminated electrons in the lung.
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spelling pubmed-70387412020-03-12 Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study Abdemanafi, Mahsa Tavakoli, Mohammad Bagher Akhavan, Ali Abedi, Iraj J Med Signals Sens Original Article BACKGROUND: Three-dimensional 3D-CRT: conformal radiation therapy is a selective modality in many radiotherapy centers for the treatment of breast cancer. One of the most common side effects of this method is radiation lung injury. Considering such an injury, lung dose deserves to be studied in depth. METHODS: Computed tomography scan of a node-positive left-sided breast cancer woman was used for generating a thorax phantom. Ten thermoluminescent dosimeters (TLDs) were distributed evenly in the left lung of the phantom, and the phantom was scanned. The optimal plan, including supraclavicular and tangential fields, was created by the treatment planning system (TPS). The results of TLD dose measurements at the selected points in the phantom were compared to TPS dose calculations. RESULTS: Lung doses calculated by TPS are significantly different from those measured by the TLDs (P = 0.007). The minimum and maximum differences were −0.91% and 4.46%, respectively. TLDs that were on the inner margin of the lung and breast tissue showed higher dose differences than the TLDs in the lung. CONCLUSION: The results of this study showed that TPS generally overestimated doses compared to TLD measurements due to incorrect beam modeling caused by contaminated electrons in the lung. Wolters Kluwer - Medknow 2020-02-06 /pmc/articles/PMC7038741/ /pubmed/32166077 http://dx.doi.org/10.4103/jmss.JMSS_1_19 Text en Copyright: © 2020 Journal of Medical Signals & Sensors http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Abdemanafi, Mahsa
Tavakoli, Mohammad Bagher
Akhavan, Ali
Abedi, Iraj
Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title_full Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title_fullStr Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title_full_unstemmed Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title_short Evaluation of the Lung Dose in Three-dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study
title_sort evaluation of the lung dose in three-dimensional conformal radiation therapy of left-sided breast cancer: a phantom study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038741/
https://www.ncbi.nlm.nih.gov/pubmed/32166077
http://dx.doi.org/10.4103/jmss.JMSS_1_19
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