Cargando…
A key interaction with RPA orients XPA in NER complexes
The XPA protein functions together with the single-stranded DNA (ssDNA) binding protein RPA as the central scaffold to ensure proper positioning of repair factors in multi-protein nucleotide excision repair (NER) machinery. We previously determined the structure of a short motif in the disordered XP...
Autores principales: | Topolska-Woś, Agnieszka M, Sugitani, Norie, Cordoba, John J, Le Meur, Kateryna V, Le Meur, Rémy A, Kim, Hyun Suk, Yeo, Jung-Eun, Rosenberg, Daniel, Hammel, Michal, Schärer, Orlando D, Chazin, Walter J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038936/ https://www.ncbi.nlm.nih.gov/pubmed/31925419 http://dx.doi.org/10.1093/nar/gkz1231 |
Ejemplares similares
-
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair
por: Kim, Mihyun, et al.
Publicado: (2022) -
Redefining
the DNA-Binding Domain of Human XPA
por: Sugitani, Norie, et al.
Publicado: (2014) -
Role of the XPA protein in the NER pathway: A perspective on the function of structural disorder in macromolecular assembly
por: Fadda, Elisa
Publicado: (2015) -
Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B
por: Cheon, Na Young, et al.
Publicado: (2019) -
Structural and functional insights into the activation of the dual incision activity of UvrC, a key player in bacterial NER
por: Seck, Anna, et al.
Publicado: (2023)