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APE1 senses DNA single-strand breaks for repair and signaling

DNA single-strand breaks (SSBs) represent the most abundant type of DNA damage. Unrepaired SSBs impair DNA replication and transcription, leading to cancer and neurodegenerative disorders. Although PARP1 and XRCC1 are implicated in the SSB repair pathway, it remains unclear how SSB repair and SSB si...

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Detalles Bibliográficos
Autores principales:	Lin, Yunfeng, Raj, Jude, Li, Jia, Ha, Anh, Hossain, Md Akram, Richardson, Christine, Mukherjee, Pinku, Yan, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038996/ https://www.ncbi.nlm.nih.gov/pubmed/31828326 http://dx.doi.org/10.1093/nar/gkz1175

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