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Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma

The present study examined SMAD family member 4 (Smad4), SMAD family member 2 (Smad2) and phosphorylated (p-)Smad2 expression in biopsy specimens from patients with invasive breast ductal carcinoma, in order to assess their abilities as prognostic markers. A total of 126 tissue samples were selected...

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Autores principales: Liu, Nannan, Qi, Dongxue, Jiang, Jing, Zhang, Jihong, Yu, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039132/
https://www.ncbi.nlm.nih.gov/pubmed/32194672
http://dx.doi.org/10.3892/ol.2020.11297
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author Liu, Nannan
Qi, Dongxue
Jiang, Jing
Zhang, Jihong
Yu, Chunyan
author_facet Liu, Nannan
Qi, Dongxue
Jiang, Jing
Zhang, Jihong
Yu, Chunyan
author_sort Liu, Nannan
collection PubMed
description The present study examined SMAD family member 4 (Smad4), SMAD family member 2 (Smad2) and phosphorylated (p-)Smad2 expression in biopsy specimens from patients with invasive breast ductal carcinoma, in order to assess their abilities as prognostic markers. A total of 126 tissue samples were selected, and the expression of Smad2, p-Smad2 and Smad4 in carcinoma tissues was detected by immunostaining, and the association between protein expression and clinicopathological variables was analyzed. Smad4 expression was negatively correlated with human epidermal growth factor receptor 2 in carcinoma tissues, and Smad4 expression was consistent with that of p-Smad2. Although multivariate analysis revealed that Smad2, p-Smad2 and Smad4 were not independent predictors, Kaplan-Meier curves demonstrated that Smad4 positivity was correlated with a longer overall survival (OS) and progression-free survival (PFS) time. However, upon analysis of combined markers, there was a significant difference between the p-Smad2/Smad4 co-positive and co-negative patients; the latter tended to exhibit a shorter OS and PFS time, and multivariate analysis revealed that the combined expression of p-Smad2 and Smad4 may be used as an independent prognostic factor. These results suggested that the assessment of p-Smad2 and Smad4 protein expression in breast ductal carcinoma biopsy specimens may provide additional prognostic information.
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spelling pubmed-70391322020-03-19 Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma Liu, Nannan Qi, Dongxue Jiang, Jing Zhang, Jihong Yu, Chunyan Oncol Lett Articles The present study examined SMAD family member 4 (Smad4), SMAD family member 2 (Smad2) and phosphorylated (p-)Smad2 expression in biopsy specimens from patients with invasive breast ductal carcinoma, in order to assess their abilities as prognostic markers. A total of 126 tissue samples were selected, and the expression of Smad2, p-Smad2 and Smad4 in carcinoma tissues was detected by immunostaining, and the association between protein expression and clinicopathological variables was analyzed. Smad4 expression was negatively correlated with human epidermal growth factor receptor 2 in carcinoma tissues, and Smad4 expression was consistent with that of p-Smad2. Although multivariate analysis revealed that Smad2, p-Smad2 and Smad4 were not independent predictors, Kaplan-Meier curves demonstrated that Smad4 positivity was correlated with a longer overall survival (OS) and progression-free survival (PFS) time. However, upon analysis of combined markers, there was a significant difference between the p-Smad2/Smad4 co-positive and co-negative patients; the latter tended to exhibit a shorter OS and PFS time, and multivariate analysis revealed that the combined expression of p-Smad2 and Smad4 may be used as an independent prognostic factor. These results suggested that the assessment of p-Smad2 and Smad4 protein expression in breast ductal carcinoma biopsy specimens may provide additional prognostic information. D.A. Spandidos 2020-03 2020-01-13 /pmc/articles/PMC7039132/ /pubmed/32194672 http://dx.doi.org/10.3892/ol.2020.11297 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Nannan
Qi, Dongxue
Jiang, Jing
Zhang, Jihong
Yu, Chunyan
Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title_full Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title_fullStr Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title_full_unstemmed Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title_short Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
title_sort expression pattern of p-smad2/smad4 as a predictor of survival in invasive breast ductal carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039132/
https://www.ncbi.nlm.nih.gov/pubmed/32194672
http://dx.doi.org/10.3892/ol.2020.11297
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