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Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival

The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gas...

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Autores principales: Yin, Shui-Ping, Gao, Yi, Xie, Xu-Shi, Xu, Dan-Dan, Riabov, Vladimir, Du, Wei-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039161/
https://www.ncbi.nlm.nih.gov/pubmed/32194740
http://dx.doi.org/10.3892/ol.2020.11310
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author Yin, Shui-Ping
Gao, Yi
Xie, Xu-Shi
Xu, Dan-Dan
Riabov, Vladimir
Du, Wei-Dong
author_facet Yin, Shui-Ping
Gao, Yi
Xie, Xu-Shi
Xu, Dan-Dan
Riabov, Vladimir
Du, Wei-Dong
author_sort Yin, Shui-Ping
collection PubMed
description The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not been evaluated. The present study investigated the expression of stabilin-1 and its association with clinicopathological parameters in patients with gastric cancer. The expression of stabilin-1 was evaluated by immunohistochemical staining of gastric cancer tissue samples of 371 Chinese patients with primary gastric adenocarcinoma. Confocal laser scanning microscopy was used to determine the cellular source of stabilin-1 in the gastric cancer tissues using anti-CD68, anti-CD163, anti-stabilin-1 and anti-secreted protein acidic and rich in cysteine antibodies. A higher number of stabilin-1-positive cells were observed in the cancer tissues of primary gastric adenocarcinoma compared with adjacent non-cancerous tissues of primary gastric adenocarcinoma (P<0.001); the majority of stabilin-1-positve cells were CD68(+)/CD163(+) macrophages. Poorly-differentiated gastric cancer tissue had fewer stabilin-1-positive cells compared with medium- and well-differentiated gastric cancer (P=0.030). A higher number of stabilin-1-positive cells were found in the early Tumor-Node-Metastasis (TNM) stage (TNM I stage) of primary gastric adenocarcinoma (P=0.038) compared with TNM stage IV. For patients with TNM stage I disease, a higher number of stabilin-1-positive TAMs was associated with shorter cumulative survival (P<0.05). Overall, stabilin-1 was found to be expressed by CD68(+) TAMs in human gastric cancer. The high expression of stabilin-1 in TNM stage I disease was associated with poor patient survival, indicating the clinical significance of stabilin-1 in gastric cancer.
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spelling pubmed-70391612020-03-19 Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival Yin, Shui-Ping Gao, Yi Xie, Xu-Shi Xu, Dan-Dan Riabov, Vladimir Du, Wei-Dong Oncol Lett Articles The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not been evaluated. The present study investigated the expression of stabilin-1 and its association with clinicopathological parameters in patients with gastric cancer. The expression of stabilin-1 was evaluated by immunohistochemical staining of gastric cancer tissue samples of 371 Chinese patients with primary gastric adenocarcinoma. Confocal laser scanning microscopy was used to determine the cellular source of stabilin-1 in the gastric cancer tissues using anti-CD68, anti-CD163, anti-stabilin-1 and anti-secreted protein acidic and rich in cysteine antibodies. A higher number of stabilin-1-positive cells were observed in the cancer tissues of primary gastric adenocarcinoma compared with adjacent non-cancerous tissues of primary gastric adenocarcinoma (P<0.001); the majority of stabilin-1-positve cells were CD68(+)/CD163(+) macrophages. Poorly-differentiated gastric cancer tissue had fewer stabilin-1-positive cells compared with medium- and well-differentiated gastric cancer (P=0.030). A higher number of stabilin-1-positive cells were found in the early Tumor-Node-Metastasis (TNM) stage (TNM I stage) of primary gastric adenocarcinoma (P=0.038) compared with TNM stage IV. For patients with TNM stage I disease, a higher number of stabilin-1-positive TAMs was associated with shorter cumulative survival (P<0.05). Overall, stabilin-1 was found to be expressed by CD68(+) TAMs in human gastric cancer. The high expression of stabilin-1 in TNM stage I disease was associated with poor patient survival, indicating the clinical significance of stabilin-1 in gastric cancer. D.A. Spandidos 2020-03 2020-01-16 /pmc/articles/PMC7039161/ /pubmed/32194740 http://dx.doi.org/10.3892/ol.2020.11310 Text en Copyright: © Yin et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yin, Shui-Ping
Gao, Yi
Xie, Xu-Shi
Xu, Dan-Dan
Riabov, Vladimir
Du, Wei-Dong
Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title_full Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title_fullStr Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title_full_unstemmed Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title_short Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
title_sort accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039161/
https://www.ncbi.nlm.nih.gov/pubmed/32194740
http://dx.doi.org/10.3892/ol.2020.11310
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