FG-nucleoporins caught in the act of liquid–liquid phase separation

The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid–liquid phase separation and f...

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Autor principal: Dormann, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039191/
https://www.ncbi.nlm.nih.gov/pubmed/31834369
http://dx.doi.org/10.1083/jcb.201910211
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author Dormann, Dorothee
author_facet Dormann, Dorothee
author_sort Dormann, Dorothee
collection PubMed
description The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid–liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.
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spelling pubmed-70391912020-07-06 FG-nucleoporins caught in the act of liquid–liquid phase separation Dormann, Dorothee J Cell Biol Commentaries The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid–liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs. Rockefeller University Press 2020-01-04 /pmc/articles/PMC7039191/ /pubmed/31834369 http://dx.doi.org/10.1083/jcb.201910211 Text en © 2019 Dormann http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Dormann, Dorothee
FG-nucleoporins caught in the act of liquid–liquid phase separation
title FG-nucleoporins caught in the act of liquid–liquid phase separation
title_full FG-nucleoporins caught in the act of liquid–liquid phase separation
title_fullStr FG-nucleoporins caught in the act of liquid–liquid phase separation
title_full_unstemmed FG-nucleoporins caught in the act of liquid–liquid phase separation
title_short FG-nucleoporins caught in the act of liquid–liquid phase separation
title_sort fg-nucleoporins caught in the act of liquid–liquid phase separation
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039191/
https://www.ncbi.nlm.nih.gov/pubmed/31834369
http://dx.doi.org/10.1083/jcb.201910211
work_keys_str_mv AT dormanndorothee fgnucleoporinscaughtintheactofliquidliquidphaseseparation

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