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Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies

Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of acoustic waves acquired by an ultrasound (US) transducer, to form an image that can provide functional and molecula...

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Autores principales: Alijabbari, Naser, Alshahrani, Suhail S., Pattyn, Alexander, Mehrmohammadi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039403/
https://www.ncbi.nlm.nih.gov/pubmed/32095283
http://dx.doi.org/10.3390/app9153094
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author Alijabbari, Naser
Alshahrani, Suhail S.
Pattyn, Alexander
Mehrmohammadi, Mohammad
author_facet Alijabbari, Naser
Alshahrani, Suhail S.
Pattyn, Alexander
Mehrmohammadi, Mohammad
author_sort Alijabbari, Naser
collection PubMed
description Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of acoustic waves acquired by an ultrasound (US) transducer, to form an image that can provide functional and molecular information. Amongst the various types of PA imaging, PA tomography (PAT) has been proposed for imaging pathologies such as breast cancer. However, the main challenge for PAT imaging is the deliverance of sufficient light energy horizontally through an imaging cross-section as well as vertically. In this study, three different illumination methods are compared for a full-ring ultrasound (US) PAT system. The three distinct illumination setups are full-ring, diffused-beam, and point source illumination. The full-ring system utilizes a cone mirror and parabolic reflector to create the ringed-shaped beam for PAT, while the diffuse scheme uses a light diffuser to expand the beam, which illuminates tissue-mimicking phantoms. The results indicate that the full-ring illumination is capable of providing a more uniform fluence irrespective of the vertical depth of the imaged cross-section, while the point source and diffused illumination methods provide a higher fluence at regions closer to the point of entry, which diminishes with depth. In addition, a set of experiments was conducted to determine the optimum position of ring-illumination with respect to the position of the acoustic detectors to achieve the highest signal-to-noise ratio.
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spelling pubmed-70394032020-08-01 Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies Alijabbari, Naser Alshahrani, Suhail S. Pattyn, Alexander Mehrmohammadi, Mohammad Appl Sci (Basel) Article Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of acoustic waves acquired by an ultrasound (US) transducer, to form an image that can provide functional and molecular information. Amongst the various types of PA imaging, PA tomography (PAT) has been proposed for imaging pathologies such as breast cancer. However, the main challenge for PAT imaging is the deliverance of sufficient light energy horizontally through an imaging cross-section as well as vertically. In this study, three different illumination methods are compared for a full-ring ultrasound (US) PAT system. The three distinct illumination setups are full-ring, diffused-beam, and point source illumination. The full-ring system utilizes a cone mirror and parabolic reflector to create the ringed-shaped beam for PAT, while the diffuse scheme uses a light diffuser to expand the beam, which illuminates tissue-mimicking phantoms. The results indicate that the full-ring illumination is capable of providing a more uniform fluence irrespective of the vertical depth of the imaged cross-section, while the point source and diffused illumination methods provide a higher fluence at regions closer to the point of entry, which diminishes with depth. In addition, a set of experiments was conducted to determine the optimum position of ring-illumination with respect to the position of the acoustic detectors to achieve the highest signal-to-noise ratio. 2019-07-31 2019-08-01 /pmc/articles/PMC7039403/ /pubmed/32095283 http://dx.doi.org/10.3390/app9153094 Text en This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alijabbari, Naser
Alshahrani, Suhail S.
Pattyn, Alexander
Mehrmohammadi, Mohammad
Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title_full Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title_fullStr Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title_full_unstemmed Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title_short Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies
title_sort photoacoustic tomography with a ring ultrasound transducer: a comparison of different illumination strategies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039403/
https://www.ncbi.nlm.nih.gov/pubmed/32095283
http://dx.doi.org/10.3390/app9153094
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