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Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit
Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to differentially deliver them to the spinal cord...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039460/ https://www.ncbi.nlm.nih.gov/pubmed/32092080 http://dx.doi.org/10.1371/journal.pone.0223700 |
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author | Zhang, Peng Li, Yao Xu, Ting |
author_facet | Zhang, Peng Li, Yao Xu, Ting |
author_sort | Zhang, Peng |
collection | PubMed |
description | Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to differentially deliver them to the spinal cord of rabbit. Sixteen New Zealand White rabbits were randomly assigned to the isoflurane or sevoflurane group. A catheter was placed into the descending aorta, and emulsified isoflurane (8mg/kg/h) or sevoflurane (12mg/kg/h) was given respectively. The concentration and partial pressure of the anesthetics in the jugular and femoral vein were measured. Our results showed that the partial pressure for isoflurane was 3.91±1.11 mmHg and 12.61±1.60 mmHg (1.0MAC), and for sevoflurane was 3.89±1.00 mmHg and 19.92±1.84mmHg (1.0MAC), in the jugular vein and femoral vein, respectively. There was significant difference between jugular and femoral vein partial pressure for both isoflurane and sevoflurane groups (both P < 0.001). In conclusion, a simple and minimally invasive method has been successfully developed to selectively deliver isoflurane and sevoflurane to the spinal cord in the rabbit. Before the anesthetics taking action on the brain, 69% of isoflurane and 81% of sevoflurane were removed through lungs. This method can be used to investigate sites and mechanisms of volatile anesthetic action. |
format | Online Article Text |
id | pubmed-7039460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70394602020-03-06 Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit Zhang, Peng Li, Yao Xu, Ting PLoS One Research Article Emulsified volatile anesthetic can be directly injected into the circulation and eliminated from blood through lungs. Taking advantage of the unique pharmacokinetics of the emulsified volatile anesthetics, we aimed to develop a less traumatic method to differentially deliver them to the spinal cord of rabbit. Sixteen New Zealand White rabbits were randomly assigned to the isoflurane or sevoflurane group. A catheter was placed into the descending aorta, and emulsified isoflurane (8mg/kg/h) or sevoflurane (12mg/kg/h) was given respectively. The concentration and partial pressure of the anesthetics in the jugular and femoral vein were measured. Our results showed that the partial pressure for isoflurane was 3.91±1.11 mmHg and 12.61±1.60 mmHg (1.0MAC), and for sevoflurane was 3.89±1.00 mmHg and 19.92±1.84mmHg (1.0MAC), in the jugular vein and femoral vein, respectively. There was significant difference between jugular and femoral vein partial pressure for both isoflurane and sevoflurane groups (both P < 0.001). In conclusion, a simple and minimally invasive method has been successfully developed to selectively deliver isoflurane and sevoflurane to the spinal cord in the rabbit. Before the anesthetics taking action on the brain, 69% of isoflurane and 81% of sevoflurane were removed through lungs. This method can be used to investigate sites and mechanisms of volatile anesthetic action. Public Library of Science 2020-02-24 /pmc/articles/PMC7039460/ /pubmed/32092080 http://dx.doi.org/10.1371/journal.pone.0223700 Text en © 2020 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhang, Peng Li, Yao Xu, Ting Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title | Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title_full | Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title_fullStr | Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title_full_unstemmed | Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title_short | Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
title_sort | development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039460/ https://www.ncbi.nlm.nih.gov/pubmed/32092080 http://dx.doi.org/10.1371/journal.pone.0223700 |
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