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Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes
AIMS/HYPOTHESIS: Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in peripheral nervous system homeostasis. The ai...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039520/ https://www.ncbi.nlm.nih.gov/pubmed/32092076 http://dx.doi.org/10.1371/journal.pone.0229145 |
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author | Jeannin, Anne-Caroline Salem, Joe-Elie Massy, Ziad Aubert, Carole Elodie Vemeer, Cees Amouyal, Chloé Phan, Franck Halbron, Marine Funck-Brentano, Christian Hartemann, Agnès Bourron, Olivier |
author_facet | Jeannin, Anne-Caroline Salem, Joe-Elie Massy, Ziad Aubert, Carole Elodie Vemeer, Cees Amouyal, Chloé Phan, Franck Halbron, Marine Funck-Brentano, Christian Hartemann, Agnès Bourron, Olivier |
author_sort | Jeannin, Anne-Caroline |
collection | PubMed |
description | AIMS/HYPOTHESIS: Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in peripheral nervous system homeostasis. The aim of this study was to evaluate factors associated with sensitive diabetic neuropathy in Type 2 Diabetes, and, in particular, dephospho-uncarboxylated MGP (dp-ucMGP), the inactive form of MGP. METHODS: 198 patients with Type 2 Diabetes were included. Presence of sensitive diabetic neuropathy was defined by a neuropathy disability score (NDS) ≥6. Plasma levels of dp-ucMGP were measured by ELISA. RESULTS: In this cohort, the mean age was 64+/-8.4 years old, and 80% of patients were men. Peripheral neuropathy was present in 15.7% of the patients and was significantly associated (r = 0.51, p<0.0001) with dp-ucMGP levels (β = -0.26, p = 0.045) after integrating effects of height (β = -0.38, p = 0.01), insulin treatment (β = 0.42, p = 0.002), retinopathy treated by laser (β = 0.26, p = 0.02), and total cholesterol levels (β = 0.3, p = 0.03) by multivariable analysis. CONCLUSIONS: The association between diabetic neuropathy and the inactive form of MGP suggests the existence of new pathophysiological pathways to explore. Further studies are needed to determine if dp-ucMGP may be used as a biomarker of sensitive neuropathy. Since dp-ucMGP is a marker of poor vitamin K status, clinical studies are warranted to explore the potential protective effect of high vitamin K intake on diabetic peripheral neuropathy. |
format | Online Article Text |
id | pubmed-7039520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70395202020-03-06 Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes Jeannin, Anne-Caroline Salem, Joe-Elie Massy, Ziad Aubert, Carole Elodie Vemeer, Cees Amouyal, Chloé Phan, Franck Halbron, Marine Funck-Brentano, Christian Hartemann, Agnès Bourron, Olivier PLoS One Research Article AIMS/HYPOTHESIS: Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in peripheral nervous system homeostasis. The aim of this study was to evaluate factors associated with sensitive diabetic neuropathy in Type 2 Diabetes, and, in particular, dephospho-uncarboxylated MGP (dp-ucMGP), the inactive form of MGP. METHODS: 198 patients with Type 2 Diabetes were included. Presence of sensitive diabetic neuropathy was defined by a neuropathy disability score (NDS) ≥6. Plasma levels of dp-ucMGP were measured by ELISA. RESULTS: In this cohort, the mean age was 64+/-8.4 years old, and 80% of patients were men. Peripheral neuropathy was present in 15.7% of the patients and was significantly associated (r = 0.51, p<0.0001) with dp-ucMGP levels (β = -0.26, p = 0.045) after integrating effects of height (β = -0.38, p = 0.01), insulin treatment (β = 0.42, p = 0.002), retinopathy treated by laser (β = 0.26, p = 0.02), and total cholesterol levels (β = 0.3, p = 0.03) by multivariable analysis. CONCLUSIONS: The association between diabetic neuropathy and the inactive form of MGP suggests the existence of new pathophysiological pathways to explore. Further studies are needed to determine if dp-ucMGP may be used as a biomarker of sensitive neuropathy. Since dp-ucMGP is a marker of poor vitamin K status, clinical studies are warranted to explore the potential protective effect of high vitamin K intake on diabetic peripheral neuropathy. Public Library of Science 2020-02-24 /pmc/articles/PMC7039520/ /pubmed/32092076 http://dx.doi.org/10.1371/journal.pone.0229145 Text en © 2020 Jeannin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jeannin, Anne-Caroline Salem, Joe-Elie Massy, Ziad Aubert, Carole Elodie Vemeer, Cees Amouyal, Chloé Phan, Franck Halbron, Marine Funck-Brentano, Christian Hartemann, Agnès Bourron, Olivier Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title | Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title_full | Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title_fullStr | Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title_full_unstemmed | Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title_short | Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes |
title_sort | inactive matrix gla protein plasma levels are associated with peripheral neuropathy in type 2 diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039520/ https://www.ncbi.nlm.nih.gov/pubmed/32092076 http://dx.doi.org/10.1371/journal.pone.0229145 |
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