TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm

The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is s...

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Detalles Bibliográficos
Autores principales: Wang, Shuo, Jia, Chenhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039625/
https://www.ncbi.nlm.nih.gov/pubmed/32079471
http://dx.doi.org/10.1080/19336950.2020.1730020
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author Wang, Shuo
Jia, Chenhong
author_facet Wang, Shuo
Jia, Chenhong
author_sort Wang, Shuo
collection PubMed
description The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is still unclear. Transient receptor potential vanilloid (TRPV) family has protective effects in cardiovascular diseases. In this study, we revealed the expression and the pathogenesis of TRPV1 in a mouse AAA model. The results presented here identify TRPV1 could be a potential therapeutic target for AAA treatment.
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spelling pubmed-70396252020-03-03 TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm Wang, Shuo Jia, Chenhong Channels (Austin) Research Paper The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is still unclear. Transient receptor potential vanilloid (TRPV) family has protective effects in cardiovascular diseases. In this study, we revealed the expression and the pathogenesis of TRPV1 in a mouse AAA model. The results presented here identify TRPV1 could be a potential therapeutic target for AAA treatment. Taylor & Francis 2020-02-21 /pmc/articles/PMC7039625/ /pubmed/32079471 http://dx.doi.org/10.1080/19336950.2020.1730020 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Wang, Shuo
Jia, Chenhong
TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title_full TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title_fullStr TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title_full_unstemmed TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title_short TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
title_sort trpv1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039625/
https://www.ncbi.nlm.nih.gov/pubmed/32079471
http://dx.doi.org/10.1080/19336950.2020.1730020
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