TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61-channel

In mammalian cells, one-third of all polypeptides is transported into or through the ER-membrane via the Sec61-channel. While the Sec61-complex facilitates the transport of all polypeptides with amino-terminal signal peptides (SP) or SP-equivalent transmembrane helices (TMH), the translocating chain...

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Detalles Bibliográficos
Autores principales: Klein, Marie-Christine, Lerner, Monika, Nguyen, Duy, Pfeffer, Stefan, Dudek, Johanna, Förster, Friedrich, Helms, Volkhard, Lang, Sven, Zimmermann, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039644/
https://www.ncbi.nlm.nih.gov/pubmed/32013668
http://dx.doi.org/10.1080/19336950.2020.1724759

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