Cargando…

EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD

Sequential mannose trimming of N-glycan (Man(9)GlcNAc(2) -> Man(8)GlcNAc(2) -> Man(7)GlcNAc(2)) facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). Our gene knockout experiments in human HCT116 cells have revealed that EDEM2 is required for the first s...

Descripción completa

Detalles Bibliográficos
Autores principales:	George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Saito, Taiki, Ishikawa, Tokiro, Sakuma, Tetsushi, Yamamoto, Takashi, Imami, Koshi, Ishihama, Yasushi, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039678/ https://www.ncbi.nlm.nih.gov/pubmed/32065582 http://dx.doi.org/10.7554/eLife.53455

Ejemplares similares

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step
por: Ninagawa, Satoshi, et al.
Publicado: (2014)

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD
por: George, Ginto, et al.
Publicado: (2021)

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes
por: Ninagawa, Satoshi, et al.
Publicado: (2020)

Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1
por: Ron, Efrat, et al.
Publicado: (2011)

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway
por: Ninagawa, Satoshi, et al.
Publicado: (2015)

Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates
por: Shenkman, Marina, et al.
Publicado: (2018)

Affinity Proteomics and Deglycoproteomics Uncover Novel EDEM2 Endogenous Substrates and an Integrative ERAD Network
por: Munteanu, Cristian V.A., et al.
Publicado: (2021)

Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation
por: Chan, Mikko C., et al.
Publicado: (2021)

A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b
por: Saito, Shunsuke, et al.
Publicado: (2022)

TXNDC5, a Newly Discovered Disulfide Isomerase with a Key Role in Cell Physiology and Pathology
por: Horna-Terrón, Elena, et al.
Publicado: (2014)

Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
por: Sokołowska, Iwona, et al.
Publicado: (2015)

Trimming ERAD
por: Tuma, Rabiya S.
Publicado: (2006)

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired
por: Chiritoiu, Marioara, et al.
Publicado: (2020)

Monitoring mitochondrial translation by pulse SILAC
por: Imami, Koshi, et al.
Publicado: (2023)

The role and mechanism of TXNDC5 in diseases
por: Wang, Xueling, et al.
Publicado: (2022)

TXNDC12 inhibits lipid peroxidation and ferroptosis
por: Tang, Lanlan, et al.
Publicado: (2023)

Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs
por: Niinae, Tomoya, et al.
Publicado: (2021)

Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice
por: Jin, Shengyu, et al.
Publicado: (2023)

Investigate Pathogenic Mechanism of TXNDC5 in Rheumatoid Arthritis
por: Wang, Lin, et al.
Publicado: (2013)

Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes
por: Ma, Fanhua, et al.
Publicado: (2017)

Glucose trimming and mannose trimming affect different phases of the maturation of Sindbis virus in infected BHK cells
por: McDowell, William, et al.
Publicado: (1987)

TurboID-EV: Proteomic Mapping of Recipient Cellular Proteins Proximal to Small Extracellular Vesicles
por: Li, Yuka, et al.
Publicado: (2023)

Comparison of Cohesive Models in EDEM and LIGGGHTS for Simulating Powder Compaction
por: Ramírez-Aragón, Cristina, et al.
Publicado: (2018)

Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis
por: Chang, Xiaotian, et al.
Publicado: (2011)

High expression of TXNDC11 indicated unfavorable prognosis of glioma
por: Peng, Peng, et al.
Publicado: (2021)

Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant
por: JANG, BO-YUN, et al.
Publicado: (2015)

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning
por: Manica, Georgiana, et al.
Publicado: (2021)

Novel Roles of Small Extracellular Vesicles in Regulating the Quiescence and Proliferation of Neural Stem Cells
por: Zhang, Jingtian, et al.
Publicado: (2021)

Application of Liquid-Liquid Extraction for N-terminal Myristoylation Proteomics
por: Tsumagari, Kazuya, et al.
Publicado: (2023)

TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG
por: Wang, Jing, et al.
Publicado: (2022)

A fresh trim provides a new look at the human mannose receptor
por: Ficko-Blean, Elizabeth
Publicado: (2021)

Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
por: Marin, Marioara B., et al.
Publicado: (2012)

Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics
por: Chirițoiu, Gabriela N., et al.
Publicado: (2021)

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer
por: Scott, Emma, et al.
Publicado: (2022)

Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence
por: Tan, Fengbo, et al.
Publicado: (2018)

The Escherichia coli S2P intramembrane protease RseP regulates ferric citrate uptake by cleaving the sigma factor regulator FecR
por: Yokoyama, Tatsuhiko, et al.
Publicado: (2021)

Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila
por: Pathak, Himani, et al.
Publicado: (2021)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Targeting EDEM protects against ER stress and improves development and survival in C. elegans
por: Ghenea, Simona, et al.
Publicado: (2022)

Numerical simulation and parameter optimization of earth auger in hilly area using EDEM software
por: Wang, Guofu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ell0q4odos1essfm2mkgfoo340