Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis comprises subversion of transcriptional regulation, through mutation and by hijacking normal chromatin regulation. Kat2a is a...

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Detalles Bibliográficos
Autores principales: Domingues, Ana Filipa, Kulkarni, Rashmi, Giotopoulos, George, Gupta, Shikha, Vinnenberg, Laura, Arede, Liliana, Foerner, Elena, Khalili, Mitra, Adao, Rita Romano, Johns, Ayona, Tan, Shengjiang, Zeka, Keti, Huntly, Brian J, Prabakaran, Sudhakaran, Pina, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039681/
https://www.ncbi.nlm.nih.gov/pubmed/31985402
http://dx.doi.org/10.7554/eLife.51754

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