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Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery

BACKGROUND: Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early posto...

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Autores principales: Ishii, Masatsugu, Itano, Osamu, Shinoda, Masahiro, Kitago, Minoru, Abe, Yuta, Hibi, Taizo, Yagi, Hiroshi, Takeuchi, Ayano, Tsujikawa, Hanako, Abe, Tokiya, Kitagawa, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039827/
https://www.ncbi.nlm.nih.gov/pubmed/32116420
http://dx.doi.org/10.3748/wjg.v26.i7.725
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author Ishii, Masatsugu
Itano, Osamu
Shinoda, Masahiro
Kitago, Minoru
Abe, Yuta
Hibi, Taizo
Yagi, Hiroshi
Takeuchi, Ayano
Tsujikawa, Hanako
Abe, Tokiya
Kitagawa, Yuko
author_facet Ishii, Masatsugu
Itano, Osamu
Shinoda, Masahiro
Kitago, Minoru
Abe, Yuta
Hibi, Taizo
Yagi, Hiroshi
Takeuchi, Ayano
Tsujikawa, Hanako
Abe, Tokiya
Kitagawa, Yuko
author_sort Ishii, Masatsugu
collection PubMed
description BACKGROUND: Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve. When determining eligibility for hepatectomy, the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy. AIM: To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery. METHODS: This study was a retrospective cohort study. We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016. Early post-hepatectomy liver failure (PHLF) was defined using the International Study Group of Liver Surgery’s definition of PHLF. Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of < 2 mg/dL and > 2.8 g/dL, respectively, and the time taken for Child-Pugh score to return to Child-Pugh class A. RESULTS: Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function. Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL than in those with type IV collagen 7S > 6 ng/mL. In additional analyses, similar results were observed in patients without chronic viral hepatitis associated with fibrosis. CONCLUSION: Preoperative type IV collagen 7S is a preoperative predictor of PHLF and long-term postoperative liver function recovery. It can also be used in patients without chronic hepatitis virus.
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spelling pubmed-70398272020-02-28 Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery Ishii, Masatsugu Itano, Osamu Shinoda, Masahiro Kitago, Minoru Abe, Yuta Hibi, Taizo Yagi, Hiroshi Takeuchi, Ayano Tsujikawa, Hanako Abe, Tokiya Kitagawa, Yuko World J Gastroenterol Retrospective Cohort Study BACKGROUND: Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve. When determining eligibility for hepatectomy, the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy. AIM: To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery. METHODS: This study was a retrospective cohort study. We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016. Early post-hepatectomy liver failure (PHLF) was defined using the International Study Group of Liver Surgery’s definition of PHLF. Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of < 2 mg/dL and > 2.8 g/dL, respectively, and the time taken for Child-Pugh score to return to Child-Pugh class A. RESULTS: Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function. Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL than in those with type IV collagen 7S > 6 ng/mL. In additional analyses, similar results were observed in patients without chronic viral hepatitis associated with fibrosis. CONCLUSION: Preoperative type IV collagen 7S is a preoperative predictor of PHLF and long-term postoperative liver function recovery. It can also be used in patients without chronic hepatitis virus. Baishideng Publishing Group Inc 2020-02-21 2020-02-21 /pmc/articles/PMC7039827/ /pubmed/32116420 http://dx.doi.org/10.3748/wjg.v26.i7.725 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Cohort Study
Ishii, Masatsugu
Itano, Osamu
Shinoda, Masahiro
Kitago, Minoru
Abe, Yuta
Hibi, Taizo
Yagi, Hiroshi
Takeuchi, Ayano
Tsujikawa, Hanako
Abe, Tokiya
Kitagawa, Yuko
Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title_full Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title_fullStr Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title_full_unstemmed Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title_short Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
title_sort pre-hepatectomy type iv collagen 7s predicts post-hepatectomy liver failure and recovery
topic Retrospective Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039827/
https://www.ncbi.nlm.nih.gov/pubmed/32116420
http://dx.doi.org/10.3748/wjg.v26.i7.725
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