Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Diabetes mellitus (DM) patients are at an increased risk of complications following influenza-virus infection, seasonal vaccination (SV) is recommended. However, SV with trivalent influenza vaccine (TIV) can induce antibody and type-I interferon (IFN) responses, and the effect of anti-DM treatment o...

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Detalles Bibliográficos
Autores principales: Saenwongsa, Wipawee, Nithichanon, Arnone, Chittaganpitch, Malinee, Buayai, Kampaew, Kewcharoenwong, Chidchamai, Thumrongwilainet, Boonyarat, Butta, Patcharavadee, Palaga, Tanapat, Takahashi, Yoshimasa, Ato, Manabu, Lertmemongkolchai, Ganjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039947/
https://www.ncbi.nlm.nih.gov/pubmed/32094377
http://dx.doi.org/10.1038/s41598-020-60213-0

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