Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in APAP-induced hepatotoxicity, the underlying mechanism remains unclear. Ferroptosis is a newly discovered type of cell death that is caused by...

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Detalles Bibliográficos
Autores principales: Yamada, Naoya, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Komada, Takanori, Kamata, Ryo, Sampilvanjil, Ariunaa, Ito, Junya, Nakagawa, Kiyotaka, Kuwata, Hiroshi, Hara, Shuntaro, Mizuta, Koichi, Sakuma, Yasunaru, Sata, Naohiro, Takahashi, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039960/
https://www.ncbi.nlm.nih.gov/pubmed/32094346
http://dx.doi.org/10.1038/s41419-020-2334-2

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