Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99

Six new pimprinine alkaloids (1–6), including four dimers, dipimprinines A–D (1–4), and two monomers, (±)-Pimprinol D (5), and pimprinone A (6), along with six known congeners (7–12), were isolated from a soil-derived actinomycete Streptomyces sp. NEAU-C99. Structures of the new compounds were eluci...

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Detalles Bibliográficos
Autores principales: Yu, Zhiyin, Jiang, Hao, Wang, Li, Yang, Feng-Xian, Huang, Jian-Ping, Liu, Chongxi, Guo, Xiaowei, Xiang, Wensheng, Huang, Sheng-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040024/
https://www.ncbi.nlm.nih.gov/pubmed/32133345
http://dx.doi.org/10.3389/fchem.2020.00095
Descripción
Sumario:Six new pimprinine alkaloids (1–6), including four dimers, dipimprinines A–D (1–4), and two monomers, (±)-Pimprinol D (5), and pimprinone A (6), along with six known congeners (7–12), were isolated from a soil-derived actinomycete Streptomyces sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations. Dipimprinines A–D (1–4) showed weak cytotoxic activities against five tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC(50) values ranging from 12.7 to 30.7 μM.

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