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Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital

BACKGROUND: Categorization of endometrial carcinomas as type I and II provides useful insights into their different risk factors, pathogenesis and biologic behaviours. AIM: To determine the immunohistochemical classifications of endometrial carcinomas in Nigerian women. DESIGN: A retrospective revie...

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Autores principales: Dawodu, Olayemi Olubunmi, Okunade, Kehinde Sharafadeen, Daramola, Adetola, Banjo, Adekunbiola Aina Fehintola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040300/
https://www.ncbi.nlm.nih.gov/pubmed/32127819
http://dx.doi.org/10.4314/ahs.v19i3.22
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author Dawodu, Olayemi Olubunmi
Okunade, Kehinde Sharafadeen
Daramola, Adetola
Banjo, Adekunbiola Aina Fehintola
author_facet Dawodu, Olayemi Olubunmi
Okunade, Kehinde Sharafadeen
Daramola, Adetola
Banjo, Adekunbiola Aina Fehintola
author_sort Dawodu, Olayemi Olubunmi
collection PubMed
description BACKGROUND: Categorization of endometrial carcinomas as type I and II provides useful insights into their different risk factors, pathogenesis and biologic behaviours. AIM: To determine the immunohistochemical classifications of endometrial carcinomas in Nigerian women. DESIGN: A retrospective review of histopathologic slides of cases of endometrial carcinomas seen at the Lagos University Teaching Hospital (LUTH) over a 5-year period. The slides were reviewed, and the diagnoses made according to the WHO nomenclature. The classification of endometrial carcinomas into Type I and II was made by immunohistochemistry using antibodies to ER, PR, p53 and Ki-67. RESULTS: Eight cases of endometrial adenocarcinoma were reported accounting for 53.3% of all endometrial malignancies. Of these, only 1 case showed the classic type I immunophenotype while type II staining pattern was seen in 4 cases. The remaining 3 cases had equivocal immunophenotypes: one was p53+ but showed ER+, PR+ and high Ki-67 index; the second was p53-, ER+, PR+ but had a high Ki-67 expression; while the last was p53-, but ER-, PR- and had high Ki-67 expression. CONCLUSION: Endometrial carcinomas in Nigerian women are more likely to be type II carcinomas. A reasonable proportion of the cases were equivocal thus requiring further categorization with molecular studies.
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spelling pubmed-70403002020-03-03 Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital Dawodu, Olayemi Olubunmi Okunade, Kehinde Sharafadeen Daramola, Adetola Banjo, Adekunbiola Aina Fehintola Afr Health Sci Articles BACKGROUND: Categorization of endometrial carcinomas as type I and II provides useful insights into their different risk factors, pathogenesis and biologic behaviours. AIM: To determine the immunohistochemical classifications of endometrial carcinomas in Nigerian women. DESIGN: A retrospective review of histopathologic slides of cases of endometrial carcinomas seen at the Lagos University Teaching Hospital (LUTH) over a 5-year period. The slides were reviewed, and the diagnoses made according to the WHO nomenclature. The classification of endometrial carcinomas into Type I and II was made by immunohistochemistry using antibodies to ER, PR, p53 and Ki-67. RESULTS: Eight cases of endometrial adenocarcinoma were reported accounting for 53.3% of all endometrial malignancies. Of these, only 1 case showed the classic type I immunophenotype while type II staining pattern was seen in 4 cases. The remaining 3 cases had equivocal immunophenotypes: one was p53+ but showed ER+, PR+ and high Ki-67 index; the second was p53-, ER+, PR+ but had a high Ki-67 expression; while the last was p53-, but ER-, PR- and had high Ki-67 expression. CONCLUSION: Endometrial carcinomas in Nigerian women are more likely to be type II carcinomas. A reasonable proportion of the cases were equivocal thus requiring further categorization with molecular studies. Makerere Medical School 2019-09 /pmc/articles/PMC7040300/ /pubmed/32127819 http://dx.doi.org/10.4314/ahs.v19i3.22 Text en © 2019 Dawodu et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Dawodu, Olayemi Olubunmi
Okunade, Kehinde Sharafadeen
Daramola, Adetola
Banjo, Adekunbiola Aina Fehintola
Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title_full Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title_fullStr Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title_full_unstemmed Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title_short Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
title_sort review of immunohistochemical typing of endometrial carcinoma at the lagos university teaching hospital
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040300/
https://www.ncbi.nlm.nih.gov/pubmed/32127819
http://dx.doi.org/10.4314/ahs.v19i3.22
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