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Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia

INTRODUCTION: Late initiation of anti-retroviral therapy (ART) is associated with low immunologic response, increase morbidity, mortality and hospitalization. Therefore, this study aimed to assess the prevalence and factors associated with late ART initiation among adult HIV patients in NorthWest Et...

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Autores principales: Anlay, Degefaye Zelalem, Tiruneh, Bewket Tadesse, Dachew, Berihun Assefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040303/
https://www.ncbi.nlm.nih.gov/pubmed/32127801
http://dx.doi.org/10.4314/ahs.v19i3.4
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author Anlay, Degefaye Zelalem
Tiruneh, Bewket Tadesse
Dachew, Berihun Assefa
author_facet Anlay, Degefaye Zelalem
Tiruneh, Bewket Tadesse
Dachew, Berihun Assefa
author_sort Anlay, Degefaye Zelalem
collection PubMed
description INTRODUCTION: Late initiation of anti-retroviral therapy (ART) is associated with low immunologic response, increase morbidity, mortality and hospitalization. Therefore, this study aimed to assess the prevalence and factors associated with late ART initiation among adult HIV patients in NorthWest Ethiopia. METHODS: Retrospective cross-sectional study was conducted among 412 HIV patients who started ART between January/2009 and December/2014. Simple random sampling technique was used to select patient records. Data were collected by using pretested and structured extraction tool. Binary logistic regression model was fitted to identify factors associated with late ART initiation. RESULT: A total of 410 participants were included for analysis after excluding 2 participants with incomplete data. The prevalence of late ART initiation was 67.3%. Age between 35–44 years(AOR=3.85; 95%CI:1.68–8.82), duration between testing and enrollment to care<1year (AOR=2.19;95%CI:1.30–3.69), secondary education (AOR=2.59; 95%CI 1.36–4.94), teritary education(AOR=3.28; 95%CI 1.25–8.64), being unmarried(AOR=1.88; 95%CI 1.13–3.03), bedridden and ambulatory patients (AOR=4.68 95%CI:1.49–14.68), other medication use before ART initiation(AOR=2.18; 95%CI 1.07–4.44), starting ART between 2009–2010 (AOR=5.94; 95%CI 2.74–12.87) and 2011–2012(AOR=2.80; 95%CI 1.31–5.96) were significantly associated with late ART initation at p-value <0.05. CONCLUSION: The prevalence of late ART initiation was high. Strengthening the mechanisms of early HIV testing and linkage to care are recommended to initiate treatment earlier.
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spelling pubmed-70403032020-03-03 Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia Anlay, Degefaye Zelalem Tiruneh, Bewket Tadesse Dachew, Berihun Assefa Afr Health Sci Articles INTRODUCTION: Late initiation of anti-retroviral therapy (ART) is associated with low immunologic response, increase morbidity, mortality and hospitalization. Therefore, this study aimed to assess the prevalence and factors associated with late ART initiation among adult HIV patients in NorthWest Ethiopia. METHODS: Retrospective cross-sectional study was conducted among 412 HIV patients who started ART between January/2009 and December/2014. Simple random sampling technique was used to select patient records. Data were collected by using pretested and structured extraction tool. Binary logistic regression model was fitted to identify factors associated with late ART initiation. RESULT: A total of 410 participants were included for analysis after excluding 2 participants with incomplete data. The prevalence of late ART initiation was 67.3%. Age between 35–44 years(AOR=3.85; 95%CI:1.68–8.82), duration between testing and enrollment to care<1year (AOR=2.19;95%CI:1.30–3.69), secondary education (AOR=2.59; 95%CI 1.36–4.94), teritary education(AOR=3.28; 95%CI 1.25–8.64), being unmarried(AOR=1.88; 95%CI 1.13–3.03), bedridden and ambulatory patients (AOR=4.68 95%CI:1.49–14.68), other medication use before ART initiation(AOR=2.18; 95%CI 1.07–4.44), starting ART between 2009–2010 (AOR=5.94; 95%CI 2.74–12.87) and 2011–2012(AOR=2.80; 95%CI 1.31–5.96) were significantly associated with late ART initation at p-value <0.05. CONCLUSION: The prevalence of late ART initiation was high. Strengthening the mechanisms of early HIV testing and linkage to care are recommended to initiate treatment earlier. Makerere Medical School 2019-09 /pmc/articles/PMC7040303/ /pubmed/32127801 http://dx.doi.org/10.4314/ahs.v19i3.4 Text en © 2019 Anlay et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Anlay, Degefaye Zelalem
Tiruneh, Bewket Tadesse
Dachew, Berihun Assefa
Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title_full Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title_fullStr Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title_full_unstemmed Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title_short Late ART Initiation among adult HIV patients at university of Gondar Hospital, NorthWest Ethiopia
title_sort late art initiation among adult hiv patients at university of gondar hospital, northwest ethiopia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040303/
https://www.ncbi.nlm.nih.gov/pubmed/32127801
http://dx.doi.org/10.4314/ahs.v19i3.4
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