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Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital

BACKGROUND: Co-existence of metabolic syndrome (MetS) and electrocardiography (ECG) abnormalities heightens the risk of sudden cardiac death. However, there is a gap in evidence of how ECG changes cluster among continental Africans with or without MetS. METHODS: We included 491 participants with int...

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Autores principales: Abiodun, Adeoye, Oladimeji, Adebayo, Bamidele, Tayo, Adewole, Adebiyi, Mayowa, Owolabi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040350/
https://www.ncbi.nlm.nih.gov/pubmed/32127858
http://dx.doi.org/10.4314/ahs.v19i4.4
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author Abiodun, Adeoye
Oladimeji, Adebayo
Bamidele, Tayo
Adewole, Adebiyi
Mayowa, Owolabi
author_facet Abiodun, Adeoye
Oladimeji, Adebayo
Bamidele, Tayo
Adewole, Adebiyi
Mayowa, Owolabi
author_sort Abiodun, Adeoye
collection PubMed
description BACKGROUND: Co-existence of metabolic syndrome (MetS) and electrocardiography (ECG) abnormalities heightens the risk of sudden cardiac death. However, there is a gap in evidence of how ECG changes cluster among continental Africans with or without MetS. METHODS: We included 491 participants with interpretable ECG tracings who were consecutively recruited into the Cardiovascular Risk Prediction Registry (CRP). CRP is a registry of newly presenting patients into cardiology clinic of the University College Hospital, Nigeria, with a main objective of cardiovascular risk stratification to prevent cardiovascular morbidity and mortality. Using the International Diabetic Federation (IDF) criteria they were divided into those with metabolic syndrome and non-metabolic syndrome. RESULTS: Four hundred and ninety-one participants comprising 48.3% women with mean age 53.72±15.2 years who met the IDF criteria with complete ECG interpretations were analyzed with 44.2% (men 38.6%; women 50.2%) of the participants having MetS while 74% had ECG abnormalities. Compared to women, men had higher mean serum total cholesterol, creatinine, smoking, and alcohol use, family history of hypertension and diabetes mellitus, QT prolongation, LVH plus or minus strain pattern, and ECG abnormalities in general. Women were heavier, had higher heart rate and proportions of MetS. ECG findings among those with or without MetS were not significantly different. In men, IDF metabolic score was associated with conduction abnormalities (p=0.039) and combined ECG abnormality (p=0.042) which became more significant with an exclusion of QT prolongation (p=0.004). Also, IDF abdominal obesity was associated with QT prolongation (p=0.017), combined ECG abnormality (p=0.034) while HDLc correlated with ECG abnormalities (0.037) in men. There was no significant associations of components of metabolic syndrome with ECG abnormalities among women. CONCLUSION: There was a high prevalence of MetS and abnormal ECG among the studied population. Abnormal ECG findings were more common in men with no differential association in people with or without MetS. However, a significant association existed between certain components of MetS and ECG abnormalities in men only. Male gender and HDLc were independent predictors of ECG Abnormalities.
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spelling pubmed-70403502020-03-03 Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital Abiodun, Adeoye Oladimeji, Adebayo Bamidele, Tayo Adewole, Adebiyi Mayowa, Owolabi Afr Health Sci Articles BACKGROUND: Co-existence of metabolic syndrome (MetS) and electrocardiography (ECG) abnormalities heightens the risk of sudden cardiac death. However, there is a gap in evidence of how ECG changes cluster among continental Africans with or without MetS. METHODS: We included 491 participants with interpretable ECG tracings who were consecutively recruited into the Cardiovascular Risk Prediction Registry (CRP). CRP is a registry of newly presenting patients into cardiology clinic of the University College Hospital, Nigeria, with a main objective of cardiovascular risk stratification to prevent cardiovascular morbidity and mortality. Using the International Diabetic Federation (IDF) criteria they were divided into those with metabolic syndrome and non-metabolic syndrome. RESULTS: Four hundred and ninety-one participants comprising 48.3% women with mean age 53.72±15.2 years who met the IDF criteria with complete ECG interpretations were analyzed with 44.2% (men 38.6%; women 50.2%) of the participants having MetS while 74% had ECG abnormalities. Compared to women, men had higher mean serum total cholesterol, creatinine, smoking, and alcohol use, family history of hypertension and diabetes mellitus, QT prolongation, LVH plus or minus strain pattern, and ECG abnormalities in general. Women were heavier, had higher heart rate and proportions of MetS. ECG findings among those with or without MetS were not significantly different. In men, IDF metabolic score was associated with conduction abnormalities (p=0.039) and combined ECG abnormality (p=0.042) which became more significant with an exclusion of QT prolongation (p=0.004). Also, IDF abdominal obesity was associated with QT prolongation (p=0.017), combined ECG abnormality (p=0.034) while HDLc correlated with ECG abnormalities (0.037) in men. There was no significant associations of components of metabolic syndrome with ECG abnormalities among women. CONCLUSION: There was a high prevalence of MetS and abnormal ECG among the studied population. Abnormal ECG findings were more common in men with no differential association in people with or without MetS. However, a significant association existed between certain components of MetS and ECG abnormalities in men only. Male gender and HDLc were independent predictors of ECG Abnormalities. Makerere Medical School 2019-12 /pmc/articles/PMC7040350/ /pubmed/32127858 http://dx.doi.org/10.4314/ahs.v19i4.4 Text en © 2019 Abiodun et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Abiodun, Adeoye
Oladimeji, Adebayo
Bamidele, Tayo
Adewole, Adebiyi
Mayowa, Owolabi
Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title_full Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title_fullStr Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title_full_unstemmed Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title_short Prevalence of ECG abnormalities among adults with metabolic syndrome in a Nigerian Teaching Hospital
title_sort prevalence of ecg abnormalities among adults with metabolic syndrome in a nigerian teaching hospital
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040350/
https://www.ncbi.nlm.nih.gov/pubmed/32127858
http://dx.doi.org/10.4314/ahs.v19i4.4
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