Cargando…

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. We show here that exposure to pro-inflammatory cytokines unmasks a marked plasticity of the β-cell regulatory landscape. We expand the repertoire of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramos-Rodríguez, Mireia, Raurell-Vila, Helena, Colli, Maikel L., Alvelos, Maria Inês, Subirana-Granés, Marc, Juan-Mateu, Jonàs, Norris, Richard, Turatsinze, Jean-Valery, Nakayasu, Ernesto S., Webb-Robertson, Bobbie-Jo M., Inshaw, Jamie R.J., Marchetti, Piero, Piemonti, Lorenzo, Esteller, Manel, Todd, John A., Metz, Thomas O., Eizirik, Décio L., Pasquali, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040466/ https://www.ncbi.nlm.nih.gov/pubmed/31676868 http://dx.doi.org/10.1038/s41588-019-0524-6

Ejemplares similares

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
por: Colli, Maikel L., et al.
Publicado: (2020)

B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
por: Bueno-Costa, Alberto, et al.
Publicado: (2019)

UMI4Cats: an R package to analyze chromatin contact profiles obtained by UMI-4C
por: Ramos-Rodríguez, Mireia, et al.
Publicado: (2021)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
por: Alvelos, Maria Inês, et al.
Publicado: (2020)

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
por: Alvelos, Maria Inês, et al.
Publicado: (2021)

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
por: Tyka, Karolina, et al.
Publicado: (2019)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
por: Szymczak, Florian, et al.
Publicado: (2022)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
por: Kaur, Simranjeet, et al.
Publicado: (2022)

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
por: Fignani, Daniela, et al.
Publicado: (2020)

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
por: Quesada-López, Tania, et al.
Publicado: (2016)

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
por: Bosi, Emanuele, et al.
Publicado: (2022)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
por: Ortis, Fernanda, et al.
Publicado: (2010)

Nova1 is a master regulator of alternative splicing in pancreatic beta cells
por: Villate, Olatz, et al.
Publicado: (2014)

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes
por: Luce, Sandrine, et al.
Publicado: (2021)

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes
por: Syed, Farooq, et al.
Publicado: (2020)

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
por: Eizirik, Décio L., et al.
Publicado: (2012)

SAT068 The Golgi Transmembrane Protein GOLM1 Maintains PD-L1 Protein Levels In Islet Beta Cells In Response To Type 1 Diabetic Inflammation
por: huang, fei, et al.
Publicado: (2023)

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016)

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
por: Balhuizen, Alexander, et al.
Publicado: (2017)

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
por: Grieco, Fabio Arturo, et al.
Publicado: (2017)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
por: Coomans de Brachène, Alexandra, et al.
Publicado: (2021)

Checks and Balances—The Limits of β-Cell Endurance to ER Stress
por: Eizirik, Decio L., et al.
Publicado: (2017)

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells
por: Moore, Fabrice, et al.
Publicado: (2012)

The Pancreatic Islet Regulome Browser
por: Mularoni, Loris, et al.
Publicado: (2017)

Extending Classification Algorithms to Case-Control Studies
por: Stanfill, Bryan, et al.
Publicado: (2019)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
por: Colli, Maikel L., et al.
Publicado: (2018)

Homeostatic T Cell Proliferation after Islet Transplantation
por: Monti, Paolo, et al.
Publicado: (2013)

The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
por: Ramos-Rodríguez, Mireia, et al.
Publicado: (2021)

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies
por: Yi, Xiaoyan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_aeruhck813s85lv9ipv174ego7