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Targeted Drug Delivery via the Use of ECM-Mimetic Materials
The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated loca...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040483/ https://www.ncbi.nlm.nih.gov/pubmed/32133350 http://dx.doi.org/10.3389/fbioe.2020.00069 |
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author | Hwang, Jeongmin Sullivan, Millicent O. Kiick, Kristi L. |
author_facet | Hwang, Jeongmin Sullivan, Millicent O. Kiick, Kristi L. |
author_sort | Hwang, Jeongmin |
collection | PubMed |
description | The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated locally controlled as well as targeted drug delivery. Extracellular matrix (ECM) molecules have generated widespread interest as drug delivery materials owing to the various biological functions of ECM. Hydrogels created using ECM molecules can provide not only biochemical and structural support to cells, but also spatial and temporal control over the release of therapeutic agents, including small molecules, biomacromolecules, and cells. In addition, the modification of drug delivery carriers with ECM fragments used as cell-binding ligands has facilitated cell-targeted delivery and improved the therapeutic efficiency of drugs through interaction with highly expressed cellular receptors for ECM. The combination of ECM-derived hydrogels and ECM-derived ligand approaches shows synergistic effects, leading to a great promise for the delivery of intracellular drugs, which require specific endocytic pathways for maximal effectiveness. In this review, we provide an overview of cellular receptors that interact with ECM molecules and discuss examples of selected ECM components that have been applied for drug delivery in both local and systemic platforms. Finally, we highlight the potential impacts of utilizing the interaction between ECM components and cellular receptors for intracellular delivery, particularly in tissue regeneration applications. |
format | Online Article Text |
id | pubmed-7040483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70404832020-03-04 Targeted Drug Delivery via the Use of ECM-Mimetic Materials Hwang, Jeongmin Sullivan, Millicent O. Kiick, Kristi L. Front Bioeng Biotechnol Bioengineering and Biotechnology The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated locally controlled as well as targeted drug delivery. Extracellular matrix (ECM) molecules have generated widespread interest as drug delivery materials owing to the various biological functions of ECM. Hydrogels created using ECM molecules can provide not only biochemical and structural support to cells, but also spatial and temporal control over the release of therapeutic agents, including small molecules, biomacromolecules, and cells. In addition, the modification of drug delivery carriers with ECM fragments used as cell-binding ligands has facilitated cell-targeted delivery and improved the therapeutic efficiency of drugs through interaction with highly expressed cellular receptors for ECM. The combination of ECM-derived hydrogels and ECM-derived ligand approaches shows synergistic effects, leading to a great promise for the delivery of intracellular drugs, which require specific endocytic pathways for maximal effectiveness. In this review, we provide an overview of cellular receptors that interact with ECM molecules and discuss examples of selected ECM components that have been applied for drug delivery in both local and systemic platforms. Finally, we highlight the potential impacts of utilizing the interaction between ECM components and cellular receptors for intracellular delivery, particularly in tissue regeneration applications. Frontiers Media S.A. 2020-02-18 /pmc/articles/PMC7040483/ /pubmed/32133350 http://dx.doi.org/10.3389/fbioe.2020.00069 Text en Copyright © 2020 Hwang, Sullivan and Kiick. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Hwang, Jeongmin Sullivan, Millicent O. Kiick, Kristi L. Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title | Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title_full | Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title_fullStr | Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title_full_unstemmed | Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title_short | Targeted Drug Delivery via the Use of ECM-Mimetic Materials |
title_sort | targeted drug delivery via the use of ecm-mimetic materials |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040483/ https://www.ncbi.nlm.nih.gov/pubmed/32133350 http://dx.doi.org/10.3389/fbioe.2020.00069 |
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