B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus

BACKGROUD: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. OBJECTIVE: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pr...

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Autores principales: Zhuang, Yan, Zhang, Jin, Li, Yiwei, Gu, Hongqin, Zhao, Jinyan, Sun, Ya, Wang, Rencheng, Zhang, Chunyan, Chen, Wen, Weng, Jianrong, Qi, Lan, Lu, Huifang, Zhang, Jiarong, Liu, Qin, He, Yinyan, Xu, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040503/
https://www.ncbi.nlm.nih.gov/pubmed/30621567
http://dx.doi.org/10.2174/1871530319666190101130300
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author Zhuang, Yan
Zhang, Jin
Li, Yiwei
Gu, Hongqin
Zhao, Jinyan
Sun, Ya
Wang, Rencheng
Zhang, Chunyan
Chen, Wen
Weng, Jianrong
Qi, Lan
Lu, Huifang
Zhang, Jiarong
Liu, Qin
He, Yinyan
Xu, Xianming
author_facet Zhuang, Yan
Zhang, Jin
Li, Yiwei
Gu, Hongqin
Zhao, Jinyan
Sun, Ya
Wang, Rencheng
Zhang, Chunyan
Chen, Wen
Weng, Jianrong
Qi, Lan
Lu, Huifang
Zhang, Jiarong
Liu, Qin
He, Yinyan
Xu, Xianming
author_sort Zhuang, Yan
collection PubMed
description BACKGROUD: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. OBJECTIVE: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. METHODS: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson’s correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. RESULTS: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. CONCLUSION: The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.
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spelling pubmed-70405032020-03-13 B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus Zhuang, Yan Zhang, Jin Li, Yiwei Gu, Hongqin Zhao, Jinyan Sun, Ya Wang, Rencheng Zhang, Chunyan Chen, Wen Weng, Jianrong Qi, Lan Lu, Huifang Zhang, Jiarong Liu, Qin He, Yinyan Xu, Xianming Endocr Metab Immune Disord Drug Targets Article BACKGROUD: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. OBJECTIVE: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. METHODS: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson’s correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. RESULTS: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. CONCLUSION: The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM. Bentham Science Publishers 2019-05 2019-05 /pmc/articles/PMC7040503/ /pubmed/30621567 http://dx.doi.org/10.2174/1871530319666190101130300 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Zhuang, Yan
Zhang, Jin
Li, Yiwei
Gu, Hongqin
Zhao, Jinyan
Sun, Ya
Wang, Rencheng
Zhang, Chunyan
Chen, Wen
Weng, Jianrong
Qi, Lan
Lu, Huifang
Zhang, Jiarong
Liu, Qin
He, Yinyan
Xu, Xianming
B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title_full B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title_fullStr B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title_full_unstemmed B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title_short B Lymphocytes Are Predictors of Insulin Resistance in Women with 
Gestational Diabetes Mellitus
title_sort b lymphocytes are predictors of insulin resistance in women with 
gestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040503/
https://www.ncbi.nlm.nih.gov/pubmed/30621567
http://dx.doi.org/10.2174/1871530319666190101130300
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