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The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results
AIM: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. METHODS: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 pha...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040511/ https://www.ncbi.nlm.nih.gov/pubmed/30289081 http://dx.doi.org/10.2174/1570161116666181005125459 |
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author | Al-Rasadi, Khalid Alhabib, Khalid F. Al-Allaf, Faisal Al-Waili, Khalid Al-Zakwani, Ibrahim AlSarraf, Ahmad Almahmeed, Wael AlSayed, Nasreen Alghamdi, Mohammad Batais, Mohammed A. Almigbal, Turky H. Alnouri, Fahad Kinsara, Abdulhalim Hammouda, Ashraf Awan, Zuhier Kary, Heba Elamin, Omer A. Zadjali, Fahad Al-Jarallah, Mohammed Shehab, Abdullah Sabbour, Hani Amin, Haitham Altaradi, Hani |
author_facet | Al-Rasadi, Khalid Alhabib, Khalid F. Al-Allaf, Faisal Al-Waili, Khalid Al-Zakwani, Ibrahim AlSarraf, Ahmad Almahmeed, Wael AlSayed, Nasreen Alghamdi, Mohammad Batais, Mohammed A. Almigbal, Turky H. Alnouri, Fahad Kinsara, Abdulhalim Hammouda, Ashraf Awan, Zuhier Kary, Heba Elamin, Omer A. Zadjali, Fahad Al-Jarallah, Mohammed Shehab, Abdullah Sabbour, Hani Amin, Haitham Altaradi, Hani |
author_sort | Al-Rasadi, Khalid |
collection | PubMed |
description | AIM: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. METHODS: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. In phase 1, suspected FH patients (category 1) were collected according to the lipid profile and clinical data obtained through hospital record systems. In phase 2, patients from category 2 (patients with a previous clinical diagnosis of FH) and category 1 were stratified into definitive, probable and possible FH according to the Dutch Lipid Clinic Network criteria. In phase 3, 500 patients with definitive and probable FH from categories 1 and 2 will undergo genetic testing for 4 common FH genes. In phase 4, these 500 patients with another 100 patients from category 3 (patients with previous genetic diagnosis of FH) will be followed for 1 year to evaluate clinical management and cardiovascular outcomes. The Gulf FH cohort was screened from a total of 34,366 patients attending out-patient clinics. RESULTS: The final Gulf FH cohort consisted of 3,317 patients (mean age: 47±12 years, 54% females). The number of patients with definitive FH is 203. In this initial phase of the study, the prevalence of (probable and definite) FH is 1/232. CONCLUSION: The prevalence of FH in the adult population of the Arabian Gulf region is high. The Gulf FH registry, a first-of-a-kind multi-national study in the Middle East region, will help in improving underdiagnosis and undertreatment of FH in the region. |
format | Online Article Text |
id | pubmed-7040511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-70405112020-03-13 The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results Al-Rasadi, Khalid Alhabib, Khalid F. Al-Allaf, Faisal Al-Waili, Khalid Al-Zakwani, Ibrahim AlSarraf, Ahmad Almahmeed, Wael AlSayed, Nasreen Alghamdi, Mohammad Batais, Mohammed A. Almigbal, Turky H. Alnouri, Fahad Kinsara, Abdulhalim Hammouda, Ashraf Awan, Zuhier Kary, Heba Elamin, Omer A. Zadjali, Fahad Al-Jarallah, Mohammed Shehab, Abdullah Sabbour, Hani Amin, Haitham Altaradi, Hani Curr Vasc Pharmacol Current Vascular Pharmacology AIM: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. METHODS: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. In phase 1, suspected FH patients (category 1) were collected according to the lipid profile and clinical data obtained through hospital record systems. In phase 2, patients from category 2 (patients with a previous clinical diagnosis of FH) and category 1 were stratified into definitive, probable and possible FH according to the Dutch Lipid Clinic Network criteria. In phase 3, 500 patients with definitive and probable FH from categories 1 and 2 will undergo genetic testing for 4 common FH genes. In phase 4, these 500 patients with another 100 patients from category 3 (patients with previous genetic diagnosis of FH) will be followed for 1 year to evaluate clinical management and cardiovascular outcomes. The Gulf FH cohort was screened from a total of 34,366 patients attending out-patient clinics. RESULTS: The final Gulf FH cohort consisted of 3,317 patients (mean age: 47±12 years, 54% females). The number of patients with definitive FH is 203. In this initial phase of the study, the prevalence of (probable and definite) FH is 1/232. CONCLUSION: The prevalence of FH in the adult population of the Arabian Gulf region is high. The Gulf FH registry, a first-of-a-kind multi-national study in the Middle East region, will help in improving underdiagnosis and undertreatment of FH in the region. Bentham Science Publishers 2020-01 2020-01 /pmc/articles/PMC7040511/ /pubmed/30289081 http://dx.doi.org/10.2174/1570161116666181005125459 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Current Vascular Pharmacology Al-Rasadi, Khalid Alhabib, Khalid F. Al-Allaf, Faisal Al-Waili, Khalid Al-Zakwani, Ibrahim AlSarraf, Ahmad Almahmeed, Wael AlSayed, Nasreen Alghamdi, Mohammad Batais, Mohammed A. Almigbal, Turky H. Alnouri, Fahad Kinsara, Abdulhalim Hammouda, Ashraf Awan, Zuhier Kary, Heba Elamin, Omer A. Zadjali, Fahad Al-Jarallah, Mohammed Shehab, Abdullah Sabbour, Hani Amin, Haitham Altaradi, Hani The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title | The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title_full | The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title_fullStr | The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title_full_unstemmed | The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title_short | The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results |
title_sort | gulf familial hypercholesterolemia registry (gulf fh): design, rationale and preliminary results |
topic | Current Vascular Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040511/ https://www.ncbi.nlm.nih.gov/pubmed/30289081 http://dx.doi.org/10.2174/1570161116666181005125459 |
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