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Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study
BACKGROUND: Conflicting recommendations exist addressing the management of direct oral anticoagulants (DOACs) for invasive dental procedures. OBJECTIVES: To determine the safety of DOAC continuation compared to warfarin continuation for dental extractions with regards to bleeding outcomes. METHODS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040537/ https://www.ncbi.nlm.nih.gov/pubmed/32110759 http://dx.doi.org/10.1002/rth2.12307 |
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author | Brennan, Yvonne Gu, Ying Schifter, Mark Crowther, Helen Favaloro, Emmanuel J. Curnow, Jennifer |
author_facet | Brennan, Yvonne Gu, Ying Schifter, Mark Crowther, Helen Favaloro, Emmanuel J. Curnow, Jennifer |
author_sort | Brennan, Yvonne |
collection | PubMed |
description | BACKGROUND: Conflicting recommendations exist addressing the management of direct oral anticoagulants (DOACs) for invasive dental procedures. OBJECTIVES: To determine the safety of DOAC continuation compared to warfarin continuation for dental extractions with regards to bleeding outcomes. METHODS: A single‐center, prospective, cohort study was performed to compare 7‐day bleeding outcomes between patients who continued their DOAC, and patients on warfarin with an International Normalized Ratio (INR) between 2.0 and 4.0. Blood tests including oral anticoagulant drug levels were measured immediately prior to extraction. The gauze used to apply pressure to the socket was weighed before and after extraction to estimate blood loss. Patients were contacted by phone 2 and 7 days after extraction. RESULTS: Eighty‐six patients on a DOAC had a total of 145 teeth extracted, and 21 patients on warfarin had 50 teeth extracted. There were no major bleeding events. The rate of minor plus clinically relevant nonmajor bleeding was comparable between the DOAC and warfarin cohorts (36% and 43%, respectively; odds ratio, 0.75; 95% confidence interval, 0.29‐1.98). Preextraction apixaban and dabigatran levels were comparable between bleeders and nonbleeders, while rivaroxaban levels were higher in those who bled. The weight change of gauze used to tamponade the socket was similar between the 2 cohorts. CONCLUSION: Dental extractions on patients continuing DOACs led to bleeding rates similar to patients on warfarin with an INR between 2.0 and 4.0. There is no need to adjust DOAC dosing prior to dental extractions. |
format | Online Article Text |
id | pubmed-7040537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70405372020-02-27 Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study Brennan, Yvonne Gu, Ying Schifter, Mark Crowther, Helen Favaloro, Emmanuel J. Curnow, Jennifer Res Pract Thromb Haemost Original Articles: Thrombosis BACKGROUND: Conflicting recommendations exist addressing the management of direct oral anticoagulants (DOACs) for invasive dental procedures. OBJECTIVES: To determine the safety of DOAC continuation compared to warfarin continuation for dental extractions with regards to bleeding outcomes. METHODS: A single‐center, prospective, cohort study was performed to compare 7‐day bleeding outcomes between patients who continued their DOAC, and patients on warfarin with an International Normalized Ratio (INR) between 2.0 and 4.0. Blood tests including oral anticoagulant drug levels were measured immediately prior to extraction. The gauze used to apply pressure to the socket was weighed before and after extraction to estimate blood loss. Patients were contacted by phone 2 and 7 days after extraction. RESULTS: Eighty‐six patients on a DOAC had a total of 145 teeth extracted, and 21 patients on warfarin had 50 teeth extracted. There were no major bleeding events. The rate of minor plus clinically relevant nonmajor bleeding was comparable between the DOAC and warfarin cohorts (36% and 43%, respectively; odds ratio, 0.75; 95% confidence interval, 0.29‐1.98). Preextraction apixaban and dabigatran levels were comparable between bleeders and nonbleeders, while rivaroxaban levels were higher in those who bled. The weight change of gauze used to tamponade the socket was similar between the 2 cohorts. CONCLUSION: Dental extractions on patients continuing DOACs led to bleeding rates similar to patients on warfarin with an INR between 2.0 and 4.0. There is no need to adjust DOAC dosing prior to dental extractions. John Wiley and Sons Inc. 2020-02-11 /pmc/articles/PMC7040537/ /pubmed/32110759 http://dx.doi.org/10.1002/rth2.12307 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals, Inc on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles: Thrombosis Brennan, Yvonne Gu, Ying Schifter, Mark Crowther, Helen Favaloro, Emmanuel J. Curnow, Jennifer Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title | Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title_full | Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title_fullStr | Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title_full_unstemmed | Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title_short | Dental extractions on direct oral anticoagulants vs. warfarin: The DENTST study |
title_sort | dental extractions on direct oral anticoagulants vs. warfarin: the dentst study |
topic | Original Articles: Thrombosis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040537/ https://www.ncbi.nlm.nih.gov/pubmed/32110759 http://dx.doi.org/10.1002/rth2.12307 |
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