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Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study

BACKGROUND: The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patien...

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Autores principales: Sejrup, Joakim K., Morelli, Vania M., Løchen, Maja‐Lisa, Njølstad, Inger, Mathiesen, Ellisiv B., Wilsgaard, Tom, Hansen, John‐Bjarne, Brækkan, Sigrid K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040547/
https://www.ncbi.nlm.nih.gov/pubmed/32110755
http://dx.doi.org/10.1002/rth2.12306
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author Sejrup, Joakim K.
Morelli, Vania M.
Løchen, Maja‐Lisa
Njølstad, Inger
Mathiesen, Ellisiv B.
Wilsgaard, Tom
Hansen, John‐Bjarne
Brækkan, Sigrid K.
author_facet Sejrup, Joakim K.
Morelli, Vania M.
Løchen, Maja‐Lisa
Njølstad, Inger
Mathiesen, Ellisiv B.
Wilsgaard, Tom
Hansen, John‐Bjarne
Brækkan, Sigrid K.
author_sort Sejrup, Joakim K.
collection PubMed
description BACKGROUND: The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. AIM: To study the combined effect of MI and prothrombotic SNPs on the risk of VTE. METHODS: Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994‐2012). DNA was genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) were estimated by categories of risk alleles and MI status. RESULTS: Patients with MI had a 1.4‐fold increased risk of VTE, and adjustments for the 5 SNPs, either alone or in combination, did not affect this relationship (adjusted HR, 1.52; 95% CI, 1.12‐2.07). In subjects without MI, an increased risk of VTE was observed for each of the individual SNPs (≥1 vs. 0 risk alleles), and the risk increased linearly with increasing number of risk alleles in the 5‐SNP score. The combination of MI and prothrombotic genotypes, either as individual SNPs or in the 5‐SNP score, did not result in an excess risk of VTE. CONCLUSION: The relationship between MI and VTE was not explained by these 5 prothrombotic genotypes. Prothrombotic genotypes did not yield an excess risk of VTE in patients with MI.
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spelling pubmed-70405472020-02-27 Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study Sejrup, Joakim K. Morelli, Vania M. Løchen, Maja‐Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John‐Bjarne Brækkan, Sigrid K. Res Pract Thromb Haemost Original Articles: Thrombosis BACKGROUND: The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. AIM: To study the combined effect of MI and prothrombotic SNPs on the risk of VTE. METHODS: Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994‐2012). DNA was genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) were estimated by categories of risk alleles and MI status. RESULTS: Patients with MI had a 1.4‐fold increased risk of VTE, and adjustments for the 5 SNPs, either alone or in combination, did not affect this relationship (adjusted HR, 1.52; 95% CI, 1.12‐2.07). In subjects without MI, an increased risk of VTE was observed for each of the individual SNPs (≥1 vs. 0 risk alleles), and the risk increased linearly with increasing number of risk alleles in the 5‐SNP score. The combination of MI and prothrombotic genotypes, either as individual SNPs or in the 5‐SNP score, did not result in an excess risk of VTE. CONCLUSION: The relationship between MI and VTE was not explained by these 5 prothrombotic genotypes. Prothrombotic genotypes did not yield an excess risk of VTE in patients with MI. John Wiley and Sons Inc. 2020-01-27 /pmc/articles/PMC7040547/ /pubmed/32110755 http://dx.doi.org/10.1002/rth2.12306 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals, Inc on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles: Thrombosis
Sejrup, Joakim K.
Morelli, Vania M.
Løchen, Maja‐Lisa
Njølstad, Inger
Mathiesen, Ellisiv B.
Wilsgaard, Tom
Hansen, John‐Bjarne
Brækkan, Sigrid K.
Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title_full Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title_fullStr Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title_full_unstemmed Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title_short Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study
title_sort myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: the tromsø study
topic Original Articles: Thrombosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040547/
https://www.ncbi.nlm.nih.gov/pubmed/32110755
http://dx.doi.org/10.1002/rth2.12306
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