Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

BACKGROUND: There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune cells to initiate the coagulation cascade. GMI‐1271, a potent small‐molecule E‐sel...

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Detalles Bibliográficos
Autores principales: Devata, Sumana, Angelini, Dana E., Blackburn, Susan, Hawley, Angela, Myers, Daniel D., Schaefer, Jordan K., Hemmer, Martina, Magnani, John L., Thackray, Helen M., Wakefield, Thomas W., Sood, Suman L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles: Thrombosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040550/
https://www.ncbi.nlm.nih.gov/pubmed/32110749
http://dx.doi.org/10.1002/rth2.12279

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