A Model for Induction of Dysplasia in Hamster Mucosal Pouch

Induction of premalignant lesions in animal models is of high value for research purposes. This study aimed to induce dysplasia in hamster mucosal pouch for investigation of dysplastic lesions using dimethylbenz(a)anthracene. The buccal pouch of 10 hamsters was painted with dimethylbenz(a)anthracene...

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Autores principales: Pourshahidi, Sara, Ghasemzadeh Hoseini, Elaheh, Ebrahimi, Hooman, Alaeddini, Mojgan, Etemad-Moghadam, Shahroo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040562/
https://www.ncbi.nlm.nih.gov/pubmed/32123881
http://dx.doi.org/10.18502/fid.v16i5.2291
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author Pourshahidi, Sara
Ghasemzadeh Hoseini, Elaheh
Ebrahimi, Hooman
Alaeddini, Mojgan
Etemad-Moghadam, Shahroo
author_facet Pourshahidi, Sara
Ghasemzadeh Hoseini, Elaheh
Ebrahimi, Hooman
Alaeddini, Mojgan
Etemad-Moghadam, Shahroo
author_sort Pourshahidi, Sara
collection PubMed
description Induction of premalignant lesions in animal models is of high value for research purposes. This study aimed to induce dysplasia in hamster mucosal pouch for investigation of dysplastic lesions using dimethylbenz(a)anthracene. The buccal pouch of 10 hamsters was painted with dimethylbenz(a)anthracene for 10 weeks every other day. At 5 and 10 weeks, they underwent histopathological analysis. Clinically, there was no change until week 7; after which mucosal thickening occurred. Hamsters scarified at 5 weeks and 10 weeks demonstrated mild and moderate dysplasia, respectively. dimethylbenz(a)anthracene is a useful tool for inducing dysplastic lesions in the buccal pouch mucosa of hamsters.
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spelling pubmed-70405622020-03-02 A Model for Induction of Dysplasia in Hamster Mucosal Pouch Pourshahidi, Sara Ghasemzadeh Hoseini, Elaheh Ebrahimi, Hooman Alaeddini, Mojgan Etemad-Moghadam, Shahroo Front Dent Short Communication Induction of premalignant lesions in animal models is of high value for research purposes. This study aimed to induce dysplasia in hamster mucosal pouch for investigation of dysplastic lesions using dimethylbenz(a)anthracene. The buccal pouch of 10 hamsters was painted with dimethylbenz(a)anthracene for 10 weeks every other day. At 5 and 10 weeks, they underwent histopathological analysis. Clinically, there was no change until week 7; after which mucosal thickening occurred. Hamsters scarified at 5 weeks and 10 weeks demonstrated mild and moderate dysplasia, respectively. dimethylbenz(a)anthracene is a useful tool for inducing dysplastic lesions in the buccal pouch mucosa of hamsters. Tehran University of Medical Sciences 2019 2019-10-15 /pmc/articles/PMC7040562/ /pubmed/32123881 http://dx.doi.org/10.18502/fid.v16i5.2291 Text en Copyright© Dental Research Center, Tehran University of Medical Sciences This work is published as an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by-nc/4). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Short Communication
Pourshahidi, Sara
Ghasemzadeh Hoseini, Elaheh
Ebrahimi, Hooman
Alaeddini, Mojgan
Etemad-Moghadam, Shahroo
A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title_full A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title_fullStr A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title_full_unstemmed A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title_short A Model for Induction of Dysplasia in Hamster Mucosal Pouch
title_sort model for induction of dysplasia in hamster mucosal pouch
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040562/
https://www.ncbi.nlm.nih.gov/pubmed/32123881
http://dx.doi.org/10.18502/fid.v16i5.2291
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