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Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance l...

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Detalles Bibliográficos
Autores principales: Sandoval-Yañez, Claudia, Castro Rodriguez, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040653/
https://www.ncbi.nlm.nih.gov/pubmed/31991703
http://dx.doi.org/10.3390/ma13030570
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author Sandoval-Yañez, Claudia
Castro Rodriguez, Cristian
author_facet Sandoval-Yañez, Claudia
Castro Rodriguez, Cristian
author_sort Sandoval-Yañez, Claudia
collection PubMed
description Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.
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spelling pubmed-70406532020-03-09 Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems Sandoval-Yañez, Claudia Castro Rodriguez, Cristian Materials (Basel) Review Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed. MDPI 2020-01-24 /pmc/articles/PMC7040653/ /pubmed/31991703 http://dx.doi.org/10.3390/ma13030570 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sandoval-Yañez, Claudia
Castro Rodriguez, Cristian
Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title_full Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title_fullStr Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title_full_unstemmed Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title_short Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems
title_sort dendrimers: amazing platforms for bioactive molecule delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040653/
https://www.ncbi.nlm.nih.gov/pubmed/31991703
http://dx.doi.org/10.3390/ma13030570
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