Persistence of H7N9 virus antibody response 2 years after infection

We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016‐September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titer...

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Autores principales: Yao, Lin, Wang, Guo‐Lin, Chen, Li‐Ling, Liu, Cheng, Duan, Li‐Jun, Gray, Gregory C., Ma, Mai‐Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040969/
https://www.ncbi.nlm.nih.gov/pubmed/31856341
http://dx.doi.org/10.1111/irv.12702
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author Yao, Lin
Wang, Guo‐Lin
Chen, Li‐Ling
Liu, Cheng
Duan, Li‐Jun
Gray, Gregory C.
Ma, Mai‐Juan
author_facet Yao, Lin
Wang, Guo‐Lin
Chen, Li‐Ling
Liu, Cheng
Duan, Li‐Jun
Gray, Gregory C.
Ma, Mai‐Juan
author_sort Yao, Lin
collection PubMed
description We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016‐September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7‐28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7‐51.2) and 73.45 (54.7‐106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long‐term antibody response at least 2 years after infection.
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spelling pubmed-70409692020-03-01 Persistence of H7N9 virus antibody response 2 years after infection Yao, Lin Wang, Guo‐Lin Chen, Li‐Ling Liu, Cheng Duan, Li‐Jun Gray, Gregory C. Ma, Mai‐Juan Influenza Other Respir Viruses Short Article We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016‐September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7‐28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7‐51.2) and 73.45 (54.7‐106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long‐term antibody response at least 2 years after infection. John Wiley and Sons Inc. 2019-12-19 2020-03 /pmc/articles/PMC7040969/ /pubmed/31856341 http://dx.doi.org/10.1111/irv.12702 Text en © 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Article
Yao, Lin
Wang, Guo‐Lin
Chen, Li‐Ling
Liu, Cheng
Duan, Li‐Jun
Gray, Gregory C.
Ma, Mai‐Juan
Persistence of H7N9 virus antibody response 2 years after infection
title Persistence of H7N9 virus antibody response 2 years after infection
title_full Persistence of H7N9 virus antibody response 2 years after infection
title_fullStr Persistence of H7N9 virus antibody response 2 years after infection
title_full_unstemmed Persistence of H7N9 virus antibody response 2 years after infection
title_short Persistence of H7N9 virus antibody response 2 years after infection
title_sort persistence of h7n9 virus antibody response 2 years after infection
topic Short Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040969/
https://www.ncbi.nlm.nih.gov/pubmed/31856341
http://dx.doi.org/10.1111/irv.12702
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