Reduced doses of dabrafenib and trametinib combination therapy for BRAF V600E-mutant non-small cell lung cancer prevent rhabdomyolysis and maintain tumor shrinkage: a case report

BACKGROUND: A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the drugs in combination therapy has not yet been reported. CASE PRESENTATION: A...

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Detalles Bibliográficos
Autores principales: Adachi, Yuta, Yanagimura, Naohiro, Suzuki, Chiaki, Ootani, Sakiko, Tanimoto, Azusa, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Yano, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041078/
https://www.ncbi.nlm.nih.gov/pubmed/32093631
http://dx.doi.org/10.1186/s12885-020-6626-9

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