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The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease
BACKGROUND: Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an independent and reliable predictor of CAD risk in postmenopausal women. METHODS: A cohort of co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041294/ https://www.ncbi.nlm.nih.gov/pubmed/32093690 http://dx.doi.org/10.1186/s12944-020-01208-8 |
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author | Guo, Qianyun Zhou, Shu Feng, Xunxun Yang, Jiaqi Qiao, Jiaming Zhao, Yingxin Shi, Dongmei Zhou, Yujie |
author_facet | Guo, Qianyun Zhou, Shu Feng, Xunxun Yang, Jiaqi Qiao, Jiaming Zhao, Yingxin Shi, Dongmei Zhou, Yujie |
author_sort | Guo, Qianyun |
collection | PubMed |
description | BACKGROUND: Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an independent and reliable predictor of CAD risk in postmenopausal women. METHODS: A cohort of consecutive 4644 postmenopausal women (aged 50 or above) undergoing coronary angiography (CAG) in Anzhen Hospital (Beijing, China) from January–December 2014 was included in the analysis. Of them, 3039 women were CAD patients, and 1605 were non-CAD subjects. RESULTS: Relative to control subjects, TG levels in CAD patients were higher and HDL-C levels were lower. In CAD patients, non-traditional lipid profile values (TC/HDL-C, AI, and AIP) were significantly elevated relative to controls. AIP was positively correlated with TC (r = 0.157), TG (r = 0.835), LDL-C (r = 0.058), non-HDL-C (r = 0.337), TC/HDL-C (r = 0.683), LDL-C/HDL-C (r = 0.437), LCI (r = 0.662), and AI (r = 0.684), and negatively correlated with HDL-C (r = − 0.682) (all P < 0.001), but was independent of age (r = − 0.022; P = 0.130) and BMI (r = 0.020, P = 0.168). Aunivariate logistic regression analysis revealed AIP to be the measured lipid parameter most closely related to CAD, and its unadjusted odds ratio was 1.824 (95% CI: 1.467–2.267, P < 0.001). After adjusting for several CAD risk factors (age, BMI, smoking, drinking, EH, DM, hyperlipidemia, and family history of CVD, AIP was still found to represent a significant CAD risk factor (OR 1.553, 95% CI: 1.234–1.955, P < 0. 001). CONCLUSION: AIP may be a powerful independent predictor of CAD risk in Chinese Han postmenopausal women, and may be superior to the traditional lipid indices. |
format | Online Article Text |
id | pubmed-7041294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70412942020-03-03 The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease Guo, Qianyun Zhou, Shu Feng, Xunxun Yang, Jiaqi Qiao, Jiaming Zhao, Yingxin Shi, Dongmei Zhou, Yujie Lipids Health Dis Research BACKGROUND: Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an independent and reliable predictor of CAD risk in postmenopausal women. METHODS: A cohort of consecutive 4644 postmenopausal women (aged 50 or above) undergoing coronary angiography (CAG) in Anzhen Hospital (Beijing, China) from January–December 2014 was included in the analysis. Of them, 3039 women were CAD patients, and 1605 were non-CAD subjects. RESULTS: Relative to control subjects, TG levels in CAD patients were higher and HDL-C levels were lower. In CAD patients, non-traditional lipid profile values (TC/HDL-C, AI, and AIP) were significantly elevated relative to controls. AIP was positively correlated with TC (r = 0.157), TG (r = 0.835), LDL-C (r = 0.058), non-HDL-C (r = 0.337), TC/HDL-C (r = 0.683), LDL-C/HDL-C (r = 0.437), LCI (r = 0.662), and AI (r = 0.684), and negatively correlated with HDL-C (r = − 0.682) (all P < 0.001), but was independent of age (r = − 0.022; P = 0.130) and BMI (r = 0.020, P = 0.168). Aunivariate logistic regression analysis revealed AIP to be the measured lipid parameter most closely related to CAD, and its unadjusted odds ratio was 1.824 (95% CI: 1.467–2.267, P < 0.001). After adjusting for several CAD risk factors (age, BMI, smoking, drinking, EH, DM, hyperlipidemia, and family history of CVD, AIP was still found to represent a significant CAD risk factor (OR 1.553, 95% CI: 1.234–1.955, P < 0. 001). CONCLUSION: AIP may be a powerful independent predictor of CAD risk in Chinese Han postmenopausal women, and may be superior to the traditional lipid indices. BioMed Central 2020-02-24 /pmc/articles/PMC7041294/ /pubmed/32093690 http://dx.doi.org/10.1186/s12944-020-01208-8 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Guo, Qianyun Zhou, Shu Feng, Xunxun Yang, Jiaqi Qiao, Jiaming Zhao, Yingxin Shi, Dongmei Zhou, Yujie The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title | The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title_full | The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title_fullStr | The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title_full_unstemmed | The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title_short | The sensibility of the new blood lipid indicator——atherogenic index of plasma (AIP) in menopausal women with coronary artery disease |
title_sort | sensibility of the new blood lipid indicator——atherogenic index of plasma (aip) in menopausal women with coronary artery disease |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041294/ https://www.ncbi.nlm.nih.gov/pubmed/32093690 http://dx.doi.org/10.1186/s12944-020-01208-8 |
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