Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature

Mycophenolate mofetil (MMF) is an immunosuppressive medication used for the management of various autoimmune diseases, and patients with bone marrow and solid organ transplants. Gastrointestinal side effects are seen 45% of the time and they include nausea (29%), vomiting (23%), constipation (38%),...

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Detalles Bibliográficos
Autores principales: Farooqi, Rehan, Kamal, Afrin, Burke, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041651/
https://www.ncbi.nlm.nih.gov/pubmed/32117661
http://dx.doi.org/10.7759/cureus.6774
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author Farooqi, Rehan
Kamal, Afrin
Burke, Carol
author_facet Farooqi, Rehan
Kamal, Afrin
Burke, Carol
author_sort Farooqi, Rehan
collection PubMed
description Mycophenolate mofetil (MMF) is an immunosuppressive medication used for the management of various autoimmune diseases, and patients with bone marrow and solid organ transplants. Gastrointestinal side effects are seen 45% of the time and they include nausea (29%), vomiting (23%), constipation (38%), diarrhea (50%-92%), and colitis (9%). In 98% of cases, resolution of diarrhea occurs within 20 days upon discontinuation of the MMF. Data is scarce regarding approach in the treatment of MMF-induced colitis. We report a case of MMF-induced colitis diagnosed by colonoscopy and histopathology. This case illustrates the challenges encountered while managing MMF-induced colitis.
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spelling pubmed-70416512020-02-29 Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature Farooqi, Rehan Kamal, Afrin Burke, Carol Cureus Internal Medicine Mycophenolate mofetil (MMF) is an immunosuppressive medication used for the management of various autoimmune diseases, and patients with bone marrow and solid organ transplants. Gastrointestinal side effects are seen 45% of the time and they include nausea (29%), vomiting (23%), constipation (38%), diarrhea (50%-92%), and colitis (9%). In 98% of cases, resolution of diarrhea occurs within 20 days upon discontinuation of the MMF. Data is scarce regarding approach in the treatment of MMF-induced colitis. We report a case of MMF-induced colitis diagnosed by colonoscopy and histopathology. This case illustrates the challenges encountered while managing MMF-induced colitis. Cureus 2020-01-25 /pmc/articles/PMC7041651/ /pubmed/32117661 http://dx.doi.org/10.7759/cureus.6774 Text en Copyright © 2020, Farooqi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Farooqi, Rehan
Kamal, Afrin
Burke, Carol
Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title_full Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title_fullStr Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title_full_unstemmed Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title_short Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
title_sort mycophenolate-induced colitis: a case report with focused review of literature
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041651/
https://www.ncbi.nlm.nih.gov/pubmed/32117661
http://dx.doi.org/10.7759/cureus.6774
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