NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186

Axon initial segment (AIS) functionality relies on a specific organization of the AIS with high enrichment of structural and functional proteins. In this issue, Torii et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907048) describe a mechanism for achieving a high density of proteins in...

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Detalles Bibliográficos
Autores principales: Abouelezz, Amr, Hotulainen, Pirta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041692/
https://www.ncbi.nlm.nih.gov/pubmed/31965148
http://dx.doi.org/10.1083/jcb.201911139
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author Abouelezz, Amr
Hotulainen, Pirta
author_facet Abouelezz, Amr
Hotulainen, Pirta
author_sort Abouelezz, Amr
collection PubMed
description Axon initial segment (AIS) functionality relies on a specific organization of the AIS with high enrichment of structural and functional proteins. In this issue, Torii et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907048) describe a mechanism for achieving a high density of proteins in the nascent AIS.
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spelling pubmed-70416922020-08-03 NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186 Abouelezz, Amr Hotulainen, Pirta J Cell Biol Spotlight Axon initial segment (AIS) functionality relies on a specific organization of the AIS with high enrichment of structural and functional proteins. In this issue, Torii et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907048) describe a mechanism for achieving a high density of proteins in the nascent AIS. Rockefeller University Press 2020-01-21 /pmc/articles/PMC7041692/ /pubmed/31965148 http://dx.doi.org/10.1083/jcb.201911139 Text en © 2020 Abouelezz and Hotulainen http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Abouelezz, Amr
Hotulainen, Pirta
NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title_full NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title_fullStr NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title_full_unstemmed NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title_short NuMA1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
title_sort numa1 facilitates the assembly of the axon initial segment by promoting the retention of neurofascin-186
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041692/
https://www.ncbi.nlm.nih.gov/pubmed/31965148
http://dx.doi.org/10.1083/jcb.201911139
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