Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

Antibody-mediated autoimmune diseases are a major health burden. However, our understanding of how self-reactive B cells escape self-tolerance checkpoints to secrete pathogenic autoantibodies remains incomplete. Here, we demonstrate that patients with monogenic immune dysregulation caused by gain-of...

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Detalles Bibliográficos
Autores principales: Lau, Anthony, Avery, Danielle T., Jackson, Katherine, Lenthall, Helen, Volpi, Stefano, Brigden, Henry, Russell, Amanda J., Bier, Julia, Reed, Joanne H., Smart, Joanne M., Cole, Theresa, Choo, Sharon, Gray, Paul E., Berglund, Lucinda J., Hsu, Peter, Wong, Melanie, O’Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Uzel, Gulbu, Notarangelo, Luigi D., Brink, Robert, Goodnow, Christopher C., Tangye, Stuart G., Deenick, Elissa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041712/
https://www.ncbi.nlm.nih.gov/pubmed/31841125
http://dx.doi.org/10.1084/jem.20191336

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