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Glial tauopathy: Neurons optional?
In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Rockefeller University Press
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041717/ https://www.ncbi.nlm.nih.gov/pubmed/31830204 http://dx.doi.org/10.1084/jem.20191915 |
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author | Walker, Lary C. |
author_facet | Walker, Lary C. |
author_sort | Walker, Lary C. |
collection | PubMed |
description | In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/jem.20190783) make the unexpected discovery that neuronal tau expression is not required for the formation of glial tau inclusions. The circumstances governing the variable cell-specificity of tauopathy thus remain to be fully defined. |
format | Online Article Text |
id | pubmed-7041717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70417172020-08-03 Glial tauopathy: Neurons optional? Walker, Lary C. J Exp Med News In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/jem.20190783) make the unexpected discovery that neuronal tau expression is not required for the formation of glial tau inclusions. The circumstances governing the variable cell-specificity of tauopathy thus remain to be fully defined. Rockefeller University Press 2019-12-12 /pmc/articles/PMC7041717/ /pubmed/31830204 http://dx.doi.org/10.1084/jem.20191915 Text en © 2019 Walker http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | News Walker, Lary C. Glial tauopathy: Neurons optional? |
title | Glial tauopathy: Neurons optional? |
title_full | Glial tauopathy: Neurons optional? |
title_fullStr | Glial tauopathy: Neurons optional? |
title_full_unstemmed | Glial tauopathy: Neurons optional? |
title_short | Glial tauopathy: Neurons optional? |
title_sort | glial tauopathy: neurons optional? |
topic | News |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041717/ https://www.ncbi.nlm.nih.gov/pubmed/31830204 http://dx.doi.org/10.1084/jem.20191915 |
work_keys_str_mv | AT walkerlaryc glialtauopathyneuronsoptional |