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Glial tauopathy: Neurons optional?

In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/...

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Detalles Bibliográficos
Autor principal: Walker, Lary C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041717/
https://www.ncbi.nlm.nih.gov/pubmed/31830204
http://dx.doi.org/10.1084/jem.20191915
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author Walker, Lary C.
author_facet Walker, Lary C.
author_sort Walker, Lary C.
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description In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/jem.20190783) make the unexpected discovery that neuronal tau expression is not required for the formation of glial tau inclusions. The circumstances governing the variable cell-specificity of tauopathy thus remain to be fully defined.
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spelling pubmed-70417172020-08-03 Glial tauopathy: Neurons optional? Walker, Lary C. J Exp Med News In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the protein than do neurons. Testing the hypothesis that the aggregated tau in glia derives from neurons, Narasimhan et al. (https://doi.org/10.1084/jem.20190783) make the unexpected discovery that neuronal tau expression is not required for the formation of glial tau inclusions. The circumstances governing the variable cell-specificity of tauopathy thus remain to be fully defined. Rockefeller University Press 2019-12-12 /pmc/articles/PMC7041717/ /pubmed/31830204 http://dx.doi.org/10.1084/jem.20191915 Text en © 2019 Walker http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Walker, Lary C.
Glial tauopathy: Neurons optional?
title Glial tauopathy: Neurons optional?
title_full Glial tauopathy: Neurons optional?
title_fullStr Glial tauopathy: Neurons optional?
title_full_unstemmed Glial tauopathy: Neurons optional?
title_short Glial tauopathy: Neurons optional?
title_sort glial tauopathy: neurons optional?
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041717/
https://www.ncbi.nlm.nih.gov/pubmed/31830204
http://dx.doi.org/10.1084/jem.20191915
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