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Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

BACKGROUND: An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protecti...

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Autores principales: Kim, Jee Wook, Byun, Min Soo, Yi, Dahyun, Lee, Jun Ho, Ko, Kang, Jeon, So Yeon, Sohn, Bo Kyung, Lee, Jun-Young, Kim, Yu Kyeong, Shin, Seong A, Sohn, Chul-Ho, Lee, Dong Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041799/
https://www.ncbi.nlm.nih.gov/pubmed/32097439
http://dx.doi.org/10.1371/journal.pmed.1003022
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author Kim, Jee Wook
Byun, Min Soo
Yi, Dahyun
Lee, Jun Ho
Ko, Kang
Jeon, So Yeon
Sohn, Bo Kyung
Lee, Jun-Young
Kim, Yu Kyeong
Shin, Seong A
Sohn, Chul-Ho
Lee, Dong Young
author_facet Kim, Jee Wook
Byun, Min Soo
Yi, Dahyun
Lee, Jun Ho
Ko, Kang
Jeon, So Yeon
Sohn, Bo Kyung
Lee, Jun-Young
Kim, Yu Kyeong
Shin, Seong A
Sohn, Chul-Ho
Lee, Dong Young
author_sort Kim, Jee Wook
collection PubMed
description BACKGROUND: An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Aβ deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain. METHODS AND FINDINGS: The present study was part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), an ongoing prospective cohort study that started in 2014. As of November 2016, 414 community-dwelling individuals with neither dementia nor alcohol-related disorders (280 cognitively normal [CN] individuals and 134 individuals with mild cognitive impairment [MCI]) between 56 and 90 years of age (mean age 70.9 years ± standard deviation 7.8; male, n [%] = 180 [43.5]) were recruited from 4 sites (i.e., 2 university hospitals and 2 public centers for dementia prevention and management) around Seoul, South Korea. All the participants underwent comprehensive clinical assessments comprising lifetime and current histories of alcohol intake and multimodal brain imaging, including [(11)C] Pittsburgh compound B positron emission tomography (PET), [(18)F] fluorodeoxyglucose (FDG) PET, and magnetic resonance imaging (MRI) scans. Lifetime and current alcohol intake were categorized as follows: no drinking, <1 standard drink (SD)/week, 1–13 SDs/week, and 14+ SDs/week. A moderate lifetime alcohol intake (1–13 SDs/week) was significantly associated with a lower Aβ positivity rate compared to the no drinking group, even after controlling for potential confounders (odds ratio 0.341, 95% confidence interval 0.163–0.714, p = 0.004). In contrast, current alcohol intake was not associated with amyloid deposition. Additionally, alcohol intake was not related to neurodegeneration of AD-signature regions or cerebral WMH volume. The present study had some limitations in that it had a cross-sectional design and depended on retrospective recall for alcohol drinking history. CONCLUSIONS: In this study, we observed in middle- and old-aged individuals with neither dementia nor alcohol-related disorders that moderate lifetime alcohol intake was associated with lower cerebral Aβ deposition compared to a lifetime history of not drinking. Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury.
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spelling pubmed-70417992020-03-06 Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study Kim, Jee Wook Byun, Min Soo Yi, Dahyun Lee, Jun Ho Ko, Kang Jeon, So Yeon Sohn, Bo Kyung Lee, Jun-Young Kim, Yu Kyeong Shin, Seong A Sohn, Chul-Ho Lee, Dong Young PLoS Med Research Article BACKGROUND: An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Aβ deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain. METHODS AND FINDINGS: The present study was part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), an ongoing prospective cohort study that started in 2014. As of November 2016, 414 community-dwelling individuals with neither dementia nor alcohol-related disorders (280 cognitively normal [CN] individuals and 134 individuals with mild cognitive impairment [MCI]) between 56 and 90 years of age (mean age 70.9 years ± standard deviation 7.8; male, n [%] = 180 [43.5]) were recruited from 4 sites (i.e., 2 university hospitals and 2 public centers for dementia prevention and management) around Seoul, South Korea. All the participants underwent comprehensive clinical assessments comprising lifetime and current histories of alcohol intake and multimodal brain imaging, including [(11)C] Pittsburgh compound B positron emission tomography (PET), [(18)F] fluorodeoxyglucose (FDG) PET, and magnetic resonance imaging (MRI) scans. Lifetime and current alcohol intake were categorized as follows: no drinking, <1 standard drink (SD)/week, 1–13 SDs/week, and 14+ SDs/week. A moderate lifetime alcohol intake (1–13 SDs/week) was significantly associated with a lower Aβ positivity rate compared to the no drinking group, even after controlling for potential confounders (odds ratio 0.341, 95% confidence interval 0.163–0.714, p = 0.004). In contrast, current alcohol intake was not associated with amyloid deposition. Additionally, alcohol intake was not related to neurodegeneration of AD-signature regions or cerebral WMH volume. The present study had some limitations in that it had a cross-sectional design and depended on retrospective recall for alcohol drinking history. CONCLUSIONS: In this study, we observed in middle- and old-aged individuals with neither dementia nor alcohol-related disorders that moderate lifetime alcohol intake was associated with lower cerebral Aβ deposition compared to a lifetime history of not drinking. Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury. Public Library of Science 2020-02-25 /pmc/articles/PMC7041799/ /pubmed/32097439 http://dx.doi.org/10.1371/journal.pmed.1003022 Text en © 2020 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Jee Wook
Byun, Min Soo
Yi, Dahyun
Lee, Jun Ho
Ko, Kang
Jeon, So Yeon
Sohn, Bo Kyung
Lee, Jun-Young
Kim, Yu Kyeong
Shin, Seong A
Sohn, Chul-Ho
Lee, Dong Young
Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title_full Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title_fullStr Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title_full_unstemmed Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title_short Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
title_sort association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041799/
https://www.ncbi.nlm.nih.gov/pubmed/32097439
http://dx.doi.org/10.1371/journal.pmed.1003022
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