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Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)—a signaling network that ultimately determines cell fate. Initially, UPR signaling aims at cytoprotection and restoration of ER homeostasis; that failing, it drives apoptotic cell death. ER...

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Detalles Bibliográficos
Autores principales:	Lam, Mable, Marsters, Scot A, Ashkenazi, Avi, Walter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041945/ https://www.ncbi.nlm.nih.gov/pubmed/31904339 http://dx.doi.org/10.7554/eLife.52291

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