An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptid...

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Detalles Bibliográficos
Autores principales: Martinez, Bryan A, Reis Rodrigues, Pedro, Nuñez Medina, Ricardo M, Mondal, Prosenjit, Harrison, Neale J, Lone, Museer A, Webster, Amanda, Gurkar, Aditi U, Grill, Brock, Gill, Matthew S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041946/
https://www.ncbi.nlm.nih.gov/pubmed/32096469
http://dx.doi.org/10.7554/eLife.49917

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