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β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery

Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all been solved for chicken ASIC1. These structures, alon...

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Detalles Bibliográficos
Autores principales:	Rook, Matthew L, Williamson, Abby, Lueck, John D, Musgaard, Maria, Maclean, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041949/ https://www.ncbi.nlm.nih.gov/pubmed/32031522 http://dx.doi.org/10.7554/eLife.51111

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