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Long‐lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5‐selective GABA(A) inverse agonist

BACKGROUND AND PURPOSE: Excessive GABAergic inhibition contributes to cognitive dysfunctions in Down syndrome (DS). Selective negative allosteric modulators (NAMs) of α5‐containing GABA(A) receptors such as the α5 inverse agonist (α5IA) restore learning and memory deficits in Ts65Dn mice, a model of...

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Detalles Bibliográficos
Autores principales:	Duchon, Arnaud, Gruart, Agnès, Albac, Christelle, Delatour, Benoît, Zorrilla de San Martin, Javier, Delgado‐García, José María, Hérault, Yann, Potier, Marie‐Claude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042104/ https://www.ncbi.nlm.nih.gov/pubmed/31652355 http://dx.doi.org/10.1111/bph.14903

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