Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells

Despite years of study, the gestational disorder preeclampsia (PE) remains poorly understood. One proposed mechanism of PE development is increased soluble VEGF receptor-1 (sFlt-1), ultimately causing angiogenic imbalance and endothelial dysfunction. The soluble protein is an alternative splice vari...

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Detalles Bibliográficos
Autores principales: Eddy, Adrian C., Chapman, Heather, Brown, David T., George, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Gene Expression & Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042122/
https://www.ncbi.nlm.nih.gov/pubmed/32039444
http://dx.doi.org/10.1042/BSR20193252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042122/
https://www.ncbi.nlm.nih.gov/pubmed/32039444
http://dx.doi.org/10.1042/BSR20193252

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