Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design

BACKGROUND: The SPYRAL HTN clinical trial program was initiated with two 80-patient pilot studies, SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED, which provided biological proof of principle that renal denervation has a blood pressure-lowering effect versus sham controls for subjects with uncontrolled hy...

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Detalles Bibliográficos
Autores principales: Böhm, Michael, Townsend, Raymond R., Kario, Kazuomi, Kandzari, David, Mahfoud, Felix, Weber, Michael A., Schmieder, Roland E., Tsioufis, Konstantinos, Hickey, Graeme L., Fahy, Martin, DeBruin, Vanessa, Brar, Sandeep, Pocock, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Trial Design
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042193/
https://www.ncbi.nlm.nih.gov/pubmed/32034481
http://dx.doi.org/10.1007/s00392-020-01595-z

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