Cold Formalin Fixation Guarantees DNA Integrity in Formalin Fixed Paraffin Embedded Tissues: Premises for a Better Quality of Diagnostic and Experimental Pathology With a Specific Impact on Breast Cancer

Formalin fixation and paraffin embedding (FFPE) represent the standard method to preserve tissue specimens for diagnostic pathology, however formalin fixation induces severe fragmentation of nucleic acids. We investigated whether formalin fixation at 4°C could preserve DNA integrity in FFPE specimen...

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Detalles Bibliográficos
Autores principales: Berrino, Enrico, Annaratone, Laura, Miglio, Umberto, Maldi, Elena, Piccinelli, Chiara, Peano, Erica, Balmativola, Davide, Cassoni, Paola, Pisacane, Alberto, Sarotto, Ivana, Venesio, Tiziana, Sapino, Anna, Marchiò, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042205/
https://www.ncbi.nlm.nih.gov/pubmed/32140450
http://dx.doi.org/10.3389/fonc.2020.00173

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